Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2024; 15(6): 1374-1380
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1374
Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic
Angelo Emilio Claro, Clelia Palanza, Marianna Mazza, Alessandro Rizzi, Andrea Corsello, Linda Tartaglione, Giuseppe Marano, Giovanna Elsa Ute Muti Schuenemann, Marta Rigoni, Alfredo Pontecorvi, Luigi Janiri, Paola Muti, Dario Pitocco
Angelo Emilio Claro, Alessandro Rizzi, Linda Tartaglione, Dario Pitocco, Diabetes Care Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy
Angelo Emilio Claro, Marta Rigoni, Paola Muti, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan 20122, Italy
Clelia Palanza, Istituto Italiano di Antropologia, ISItA, Rome 00100, Italy
Marianna Mazza, Giuseppe Marano, Luigi Janiri, Unit of Psychiatry, Department of Neurosciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Andrea Corsello, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Giovanna Elsa Ute Muti Schuenemann, Health Research Methods, Evidence and Impact Department, McMaster University, Ontario 1280, Canada
Alfredo Pontecorvi, Department of Endocrine-Metabolic and Dermo-Rheumatology, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Author contributions: Claro AE and Palanza C designed the study and wrote the first draft of the manuscript; Mazza M, Marano G, Rizzi A, Tartaglione L, Muti Schuenemann GEU, Corsello A, Rigoni M, Muti P, Pontecorvi A, Janiri L, and Pitocco D supervised and added important contributions to the paper; and all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: The authors declare that they do not have any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marianna Mazza, MD, PhD, Assistant Professor, Department of Neurosciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, 8 Largo A Gemelli, Rome 00168, Italy. mariannamazza@hotmail.com
Received: January 27, 2024
Revised: February 27, 2024
Accepted: April 18, 2024
Published online: June 15, 2024
Processing time: 135 Days and 21.6 Hours
Core Tip

Core Tip: Common psychiatric disorders (CPDs) and depression are important contributors to the epidemic of type 2 diabetes (T2D). Bridge-Symptoms of depression and CPDs, promote the onset of emotional eating, activation of the reward system and the development of overweight/obesity and T2D. The efficacy of naltrexone-bupropion in the treatment of overweight/obesity and drug addiction and the emerging evidence of the possible effectiveness of glucagon-like peptide 1 receptor agonists in drug addiction support our hypothesis. We propose insights to interpret the higher prevalence of CPDs and depression in patients with T2D compared to the general population and to improve the integrated psychiatric-diabetic therapy.