Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion

doi:10.4239/wjd.v15.i6.1340

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2024; 15(6): 1340-1352
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1340

Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion

Zi-Tian Liu, Guang-Wei Yang, Xiang Zhao, Shuo-Hui Dong, Yang Jiao, Zheng Ge, Ao Yu, Xi-Qiang Zhang, Xin-Zhen Xu, Zhi-Qiang Cheng, Xiang Zhang, Ke-Xin Wang

Zi-Tian Liu, Guang-Wei Yang, Xiang Zhao, Shuo-Hui Dong, Zheng Ge, Ao Yu, Xi-Qiang Zhang, Xin-Zhen Xu, Zhi-Qiang Cheng, Xiang Zhang, Ke-Xin Wang, Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China

Yang Jiao, Department of General Surgery, Shandong University of Qilu Hospital (Qingdao), Qingdao 266000, Shandong Province, China

Author contributions: Zhang X and Cheng ZQ designed the study; Liu ZT performed the research; Yang GW, Zhao X, Dong SH performed data collection and analysis; Liu ZT analyzed the data and wrote the manuscript; Jiao Y, Ge Z, Yu A, Zhang XQ, Xu XZ provided data curation; Wang KX provided funding acquisition and supervision; all authors have read and approve the final manuscript.

Supported by National Natural Science Foundation of China (General Program), No. 82070852 and No. 82270901.

Institutional animal care and use committee statement: The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Application Format for Ethical Approval for Research Involving Animals, Qilu Hosipital of Shandong University (protocol code DWLL-2021-033, The application was passed in July 2021).

Conflict-of-interest statement: The authors declare no conflict of interest.

Data sharing statement: The data presented in this study are openly available in GEO (accession number: GSE243812).

ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ke-Xin Wang, Doctor, Doctor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. wkx3726@163.com

Received: February 19, 2024
Revised: March 12, 2024
Accepted: April 15, 2024
Published online: June 15, 2024

Core Tip

Core Tip: Our results provide focused insight into the effects of duodenal-jejunal bypass (DJB) on adipose tissue function and insulin resistance in diabetic male rats. Unlike previous studies that often focused on broader metabolic improvements after DJB, this study focused on adipocytes and their molecular changes. Establishing a link between growth hormone (GH), adiponectin, and insulin sensitivity by identifying alterations in the GH pathway.