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World J Diabetes. Jun 15, 2024; 15(6): 1187-1198
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1187
Dysregulated microRNAs in type 2 diabetes and breast cancer: Potential associated molecular mechanisms
Alex Cleber Improta-Caria, Filipe Ferrari, João Lucas Penteado Gomes, Paloma Brasilio Villalta, Úrsula Paula Renó Soci, Ricardo Stein, Edilamar M Oliveira
Alex Cleber Improta-Caria, João Lucas Penteado Gomes, Úrsula Paula Renó Soci, Edilamar M Oliveira, Laboratory of Biochemistry and Molecular Biology of the Exercise, Physical Education and Sport School, University of São Paulo, São Paulo 05508-030, Brazil
Filipe Ferrari, Ricardo Stein, Graduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035003, Brazil
Paloma Brasilio Villalta, Laboratory of Metabolic Disorders (Labdime), School of Applied Sciences, University of Campinas-UNICAMP, Campinas 13484-350, Brazil
Edilamar M Oliveira, Departments of Internal Medicine, Molecular Pharmacology and Physiology, Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, United States
Author contributions: Improta-Caria AC and Oliveira EM designed the research; Improta-Caria AC, Ferrari F, Gomes JLP, Villalta PB and Soci UPR performed the research; Improta-Caria AC, Ferrari F, Gomes JLP, Villalta PB and Soci UPR wrote the paper; Improta-Caria AC, Ferrari F, Gomes JLP, Villalta PB, Soci UPR, Stein R and Oliveira EM analyzed the data; Improta-Caria AC, Stein R and Oliveira EM supervised the intellectual content.
Supported by Sao Paulo Research Foundation, No. 2022/02339-4; and Conselho Nacional de Desenvolvimento Científico e Tecnológico, No. 313376/2021-2 and No. 313479/2017-8.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alex Cleber Improta-Caria, MSc, PhD, Professor, Researcher, Laboratory of Biochemistry and Molecular Biology of the Exercise, Physical Education and Sport School, University of São Paulo, 65 Vila Universitaria, São Paulo 05508-030, Brazil. alexcaria.personal@hotmail.com
Received: December 31, 2023
Revised: March 3, 2024
Accepted: April 26, 2024
Published online: June 15, 2024
Processing time: 162 Days and 16.8 Hours
Core Tip

Core Tip: "Dysregulated microRNAs (miRNAs) in Type 2 diabetes (T2D) and breast cancer (BC): Potential Associated Molecular Mechanisms" is an innovative work that seeks to elucidate cellular and molecular mechanisms associated with T2D and BC regulated by miRNAs. Several dysregulated miRNAs were identified in both diseases and subsequently we created a Venn diagram identifying 9 overlapping miRNAs in the two diseases. Finally, we carried out an exploratory analysis of these 9 miRNAs and with the help of DIANA Tools we created a heatmap showing biological processes regulated by these miRNAs.