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World J Diabetes. Jun 15, 2024; 15(6): 1162-1177
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1162
Adipose-derived stem cells in diabetic foot care: Bridging clinical trials and practical application
Song-Lu Tseng, Lin Kang, Zhu-Jun Li, Li-Quan Wang, Zi-Ming Li, Tian-Hao Li, Jie-Yu Xiang, Jiu-Zuo Huang, Nan-Ze Yu, Xiao Long
Song-Lu Tseng, Department of Plastic and Reconstructive Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Song-Lu Tseng, Zhu-Jun Li, Li-Quan Wang, Zi-Ming Li, Tian-Hao Li, Jie-Yu Xiang, Jiu-Zuo Huang, Nan-Ze Yu, Xiao Long, Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Lin Kang, Biomedical Engineering Facility, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing, Beijing 100021, China
Author contributions: Tseng SL was responsible for data organization and manuscript drafting; Kang L undertook the manuscript editing and correction process; Li ZJ, Wang LQ, Li ZM, Li TH and Xiang JY contributed to the revision of figures and tables within the manuscript; Huang JZ, Yu NZ, X and Long X were involved in establishing the conceptual framework and overall structure of the manuscript; All authors have read and approve the final manuscript.
Supported by National Key R&D Program of China, No. 2020YFE0201600; CAMS Innovation Fund for Medical Sciences, No. 2020-I2M- C&T-A-004; and National High Level Hospital Clinical Research Funding, No. 2022-PUMCH-B-041, No. 2022-PUMCH-A-210 and No. 2022-PUMCH-C-025.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao Long, MD, PhD, Chief Physician, Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. pumclongxiao@126.com
Received: December 20, 2023
Revised: March 3, 2024
Accepted: April 19, 2024
Published online: June 15, 2024
Processing time: 173 Days and 16.7 Hours
Core Tip

Core Tip: This review critically analyzes the current state of research on the efficacy of adipose-derived stem cells (ADSCs) against diabetic foot ulcers (DFUs). It offers a comprehensive overview of diabetic foot classification, clinical management, and the ADSC therapy intricacies. Despite its potential, the field faces challenges like biased trial designs, ambiguous inclusion criteria and intervention strategies. The review highlights these issues and discusses the preclinical efforts to enhance ADSC efficacy. It emphasizes the necessity of more rigorous research and refinement of therapeutic approaches to improve treatment outcomes in diabetic wound care and guide future research.