Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2024; 15(6): 1051-1059
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1051
Monogenic diabetes in children: An underdiagnosed and poorly managed clinical dilemma
Saptarshi Bhattacharya, Joseph M Pappachan
Saptarshi Bhattacharya, Department of Endocrinology, Indraprastha Apollo Hospitals, Delhi 110076, India
Joseph M Pappachan, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom
Joseph M Pappachan, Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, United Kingdom
Joseph M Pappachan, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, United Kingdom
Author contributions: Bhattacharya S wrote the initial draft of the manuscript with some help from Pappachan JM by performing literature search, interpretation of relevant scientific data, and compiling the best evidence; He also contributed to the critical revision, important intellectual content and figure preparation for the paper; Pappachan JM contributed to the conceptual design of the paper and provided additional input to the drafting, literature review, revision and modifications of the paper; All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joseph M Pappachan, MD, FRCP, Academic Editor, Professor, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Received: December 2, 2023
Revised: March 6, 2024
Accepted: April 22, 2024
Published online: June 15, 2024
Core Tip

Core Tip: Monogenic diabetes forms a spectrum of single gene disorders, characterized by distinct patterns of inheritance, accounting for about 1%–2% of diabetes mellitus burden in the world. Although more than 50 unique genetic mutations associated with these disorders have been identified to date, the diagnosis and management of monogenic diabetes are still inadequate globally because of the poor awareness and professional inertia among physicians. Prompt suspicion and diagnostic evaluation of these disorders are of paramount importance from the management and genetic counselling perspectives. A clinical update review in the World Journal of Diabetes empowers physicians to have a better understanding about this disease.