Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2024; 15(3): 519-529
Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.519
Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina
Jian Tan, Ang Xiao, Lin Yang, Yu-Lin Tao, Yi Shao, Qiong Zhou
Jian Tan, Ang Xiao, Lin Yang, Yu-Lin Tao, Yi Shao, Qiong Zhou, Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Co-first authors: Jian Tan and Ang Xiao.
Author contributions: Tan J, Xiao A, Yang L, Tao YL, Shao Y and Zhou Q designed the research study; Tan J, Xiao A and Yang L performed the research; Tan J and Shao Y contributed new reagents and analytic tools; Tan J and Zhou Q analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript. Tan J and Xiao A contributed equally to this work as co-first authors. The reasons for designating Tan J and Xiao A as co-first authors are threefold. First, Tan J and Xiao A made equal contributions to the project research. Secondly, both Tan J and Xiao A actively participated in subsequent revisions and communication related to the paper. Finally, co-authorship serves to better exemplify collaboration within the team. In summary, we believe that designating Tan J and Xiao A as co-first authors of is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Supported by National Natural Science Foundation of China, No. 82260211; Key Research and Development Project in Jiangxi Province, No. 20203BBG73058; Chinese Medicine Science and Technology Project in Jiangxi Province, No. 2020A0166.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Nanchang University.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the First Affiliated Hospital of Nanchang University.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at zqndyfy@163.com.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiong Zhou, Doctor, Professor, Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. zqndyfy@163.com
Received: October 12, 2023
Peer-review started: October 12, 2023
First decision: December 6, 2023
Revised: December 8, 2023
Accepted: January 18, 2024
Article in press: January 18, 2024
Published online: March 15, 2024
Core Tip

Core Tip: To investigate the role and associated underlying mechanisms of receptor for activated C kinase 1 (RACK1) in the development of early diabetic retinopathy (DR). In this study, Sprague-Dawley rats and adult retinal pigment epithelium (RPE) cell line-19 cells were used as in vivo and in vitro models, respectively, to explore the role of RACK1 in mediating protein kinase C-ε in early DR. RACK1 plays a significant role in the development of early DR, and may serve as a potential therapeutic target for DR by regulating the apoptosis and barrier function of RPE cells.