Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2024; 15(2): 260-274
Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.260
Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p
Yin-Xi He, Ting Wang, Wen-Xian Li, Yan-Xia Chen
Yin-Xi He, Department of Orthopaedic Trauma, The Third Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei Province, China
Ting Wang, Yan-Xia Chen, Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Wen-Xian Li, Department of Endocrinology, The First Hospital of Zhangjiakou, Zhangjiakou 075000, Hebei Province, China
Author contributions: Chen YX conceived or supervised the study; He YX designed experiments; He YX and Wang T performed experiments; Li WX analyzed data; He YX and Chen YX wrote the manuscript; Chen YX made manuscript revisions; and all authors have read and approve the final manuscript.
Supported by the Natural Science Funds for Young Scholar of Hebei, China, No. H2020206108; and the Subject of Health Commission of Hebei, China, No. 20210151.
Institutional animal care and use committee statement: All experimental procedures were in accordance with the institutional animal care and use committee and approved by the Animal Care and Ethics Committee of Second Hospital of Hebei Medical University (approval No. 2022-AE051).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at chenbs2013@163.com.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Xia Chen, Doctor, Department of Endocrinology, The Second Hospital of Hebei Medical University, No. 215 Hepingxi Road, Shijiazhuang 050000, Hebei Province, China. chenyx@hebmu.edu.cn
Received: September 24, 2023
Peer-review started: September 24, 2023
First decision: December 6, 2023
Revised: December 13, 2023
Accepted: January 15, 2024
Article in press: January 15, 2024
Published online: February 15, 2024
Core Tip

Core Tip: The expression of long noncoding RNA (lncRNA) protein-disulfide isomerase-associated 3 (Pdia3) was significantly downregulated in high glucose (HG)-cultured podocytes. LncRNA Pdia3 was involved in HG-induced podocyte apoptosis. LncRNA Pdia3 overexpression attenuated HG-induced podocyte apoptosis and endoplasmic reticulum stress by acting as a competing endogenous RNA of miR-139-3p.