Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2024; 15(12): 2394-2398
Published online Dec 15, 2024. doi: 10.4239/wjd.v15.i12.2394
Role of intestinal glucagon-like peptide-1 in impaired counter-regulatory responses to hypoglycemia
Manjunath Havalappa Dodamani, Juniali Hatwal, Akash Batta
Manjunath Havalappa Dodamani, Department of Endocrinology, Rukmini Hormone Superspeciality Hospital, Bagalkot 587101, Karnātaka, India
Juniali Hatwal, Department of Internal Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India
Akash Batta, Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Author contributions: Dodamani MH and Batta A designed the Editorial; Dodamani MH, Hatwal J, and Batta A performed the literature review and data collection; Dodamani MH and Batta A supervised the study and provided key feedback and suggestions; Dodamani MH analyzed the data, and wrote and revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akash Batta, MD, Assistant Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Received: July 28, 2024
Revised: October 8, 2024
Accepted: October 23, 2024
Published online: December 15, 2024
Processing time: 112 Days and 18.7 Hours
Core Tip

Core Tip: Glucagon-like peptide-1 (GLP-1), an incretin hormone, plays an important role in blood glucose homeostasis, especially during the prandial phase. Excessive intestinal GLP-1 is correlated with reduced secretion of catecholamines and decreased appetite in type 1 diabetes mellitus mice exposed to recurrent hypoglycemic episodes resulting in impaired counter-regulatory responses to hypoglycemia. The index study of diabetic mice by Jin et al highlights the significant role of intestinal GLP-1 in impairment of hypoglycemia-induced counter-regulatory responses.