Zhuang LG, Zhang R, Jin GX, Pei XY, Wang Q, Ge XX. Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study. World J Diabetes 2024; 15(10): 2111-2122 [DOI: 10.4239/wjd.v15.i10.2111]
Corresponding Author of This Article
Xiao-Xu Ge, MD, Doctor, Department of Endocrinology, Tongren Hospital Affiliated to Shanghai Jiao Tong University, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. uyhyt41964@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Oct 15, 2024; 15(10): 2111-2122 Published online Oct 15, 2024. doi: 10.4239/wjd.v15.i10.2111
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study
Lan-Gen Zhuang, Rong Zhang, Guo-Xi Jin, Xiao-Yan Pei, Qiong Wang, Xiao-Xu Ge
Lan-Gen Zhuang, Guo-Xi Jin, Xiao-Yan Pei, Qiong Wang, Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui Province, China
Rong Zhang, Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Xiao-Xu Ge, Department of Endocrinology, Tongren Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200336, China
Author contributions: Zhuang LG and Ge XX participated in literature search, study design, and manuscript writing and critical revision; Zhang R, Jin GX, Pei XY, and Wang Q participated in data collection, analysis, and interpretation; and all authors read and approved the final manuscript.
Supported bythe General Project of Anhui Provincial Health and Construction Commission, No. AHWJ2022b056.
Institutional animal care and use committee statement: This animal study was reviewed and approved by the Ethics Committee of Bengbu Medical College (approval No. 2022-117).
Conflict-of-interest statement: Lan-Gen Zhuang has received research funding from the Natural Science Research Project of Anhui Educational Committee and the General project of Anhui Provincial Health and Construction Commission. Other authors declare that there are no conflicts of interest to disclose for this article.
Data sharing statement: The datasets used or/and analyzed during the current study are available from the corresponding author upon email request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Xu Ge, MD, Doctor, Department of Endocrinology, Tongren Hospital Affiliated to Shanghai Jiao Tong University, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. uyhyt41964@163.com
Received: March 7, 2024 Revised: May 30, 2024 Accepted: July 22, 2024 Published online: October 15, 2024 Processing time: 202 Days and 20.2 Hours
Core Tip
Core Tip: This study investigated the protective effects of asiaticoside (AC) in diabetic nephropathy (DN) using in vitro and in vivo models. AC attenuated high glucose-induced proliferation, inflammation, oxidative stress, and fibrosis in rat glomerular mesangial cells. In a streptozotocin-induced DN rat model, AC ameliorated renal injury, and reduced inflammatory cytokines, oxidative stress markers, and fibrogenic markers. Notably, the renoprotective effects of AC were associated with the activation of the nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 antioxidant signaling pathway, suggesting AC’s therapeutic potential for DN by targeting inflammation, oxidative stress, and fibrosis through NRF2-associated mechanisms.
