Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2024; 15(10): 2081-2092
Published online Oct 15, 2024. doi: 10.4239/wjd.v15.i10.2081
Association between sensitivity to thyroid hormones and non-high-density lipoprotein cholesterol levels in patients with type 2 diabetes mellitus
Xiao-Ye Duan, Jun-Ling Fu, Li-Na Sun, Zhi-Jing Mu, Shuang-Ling Xiu
Xiao-Ye Duan, Jun-Ling Fu, Li-Na Sun, Zhi-Jing Mu, Shuang-Ling Xiu, Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Author contributions: Duan XY analyzed the data and wrote the manuscript; Fu JL, Sun LN and Mu ZJ contributed to the data collection; Xiu SL contributed to the data interpretation and reviewed the manuscript; all the authors read and approved the submitted version of the manuscript.
Supported by the Xuanwu Hospital Capital Medical University Science Program for Fostering Young Scholars, No. YC20220113; and the Pilot Project for Public, No. Beijing Medical Research 2021-8.
Institutional review board statement: The study was reviewed and approved by the Research Ethics Boards at Xuanwu Hospital (CTR-2020075).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shuang-Ling Xiu, PhD, Doctor, Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Changchun Street, Beijing 100053, China. xiushuangling@126.com
Received: May 6, 2024
Revised: August 6, 2024
Accepted: August 30, 2024
Published online: October 15, 2024
Processing time: 143 Days and 2.8 Hours
Core Tip

Core Tip: Reduced central thyroid hormone sensitivity was an independent risk factor of high non-high-density lipoprotein cholesterol (non-HDL-C), even after adjusting for multiple confounding factors. The patients with hyper-non-HDL-C were more susceptible to metabolic disorders and impaired sensitivity to thyroid hormones. Meanwhile, the relationships between thyroid hormone sensitivity and non-HDL-C levels were different in male and female, indicating a gender-related regulation of thyroid hormones on serum non-HDL-C levels. This study may provide new evidence for the role of reduced thyroid hormone sensitivity for non-HDL-C levels and lie the groundwork for future therapeutic strategies for diabetes-related cardiovascular disease risk.