Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

doi:10.4239/wjd.v15.i10.2041

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Oct 15, 2024 (publication date) through Sep 26, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Oct 15, 2024; 15(10): 2041-2057
Published online Oct 15, 2024. doi: 10.4239/wjd.v15.i10.2041

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

Ming-Wei Fan, Jin-Lan Tian, Tan Chen, Can Zhang, Xin-Ru Liu, Zi-Jian Zhao, Shu-Hui Zhang, Yan Chen

Ming-Wei Fan, Jin-Lan Tian, Tan Chen, Can Zhang, Xin-Ru Liu, Zi-Jian Zhao, Shu-Hui Zhang, Yan Chen, Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China

Co-first authors: Ming-Wei Fan and Jin-Lan Tian.

Co-corresponding authors: Shu-Hui Zhang and Yan Chen.

Author contributions: Fan MW and Tian JL contributed equally to this study as they are co-first authors of this manuscript. Fan MW, Zhang SH, and Chen Y discussed the data; Tian JL, Chen T, Zhang C, Liu XR, and Zhao ZJ drafted the manuscript and also took responsibility of the data analysis. Zhang SH and Chen Y contributed equally to this study as they are co- corresponding authors of this manuscript.

Supported by the Natural Science Foundation of Shandong Province, No. ZR2022MH153; and “Clinical + X” Project Fund of Binzhou Medical College, No. BY2021LCX11.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yan Chen, PhD, Professor, Department of Gastroenterology, Binzhou Medical University Hospital, No. 661 Yellow River Second Road, Bincheng District, Binzhou 256600, Shandong Province, China. chenyanfeihong0906@163.com

Received: May 18, 2024
Revised: August 14, 2024
Accepted: August 26, 2024
Published online: October 15, 2024
Processing time: 131 Days and 6.1 Hours

Core Tip

Core Tip: Inflammation mediated by the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is closely related to the occurrence and development of diabetes and its complications. This article focuses on the specific mechanism of cGAS-STING signaling pathway in mediating inflammatory response as well as the role of cGAS-STING signaling in complications such as diabetes, diabetic gastroenteropathy, diabetic cardiomyopathy, and non-alcoholic fatty liver disease, along with the role of transmission pathways and the related research progress.