Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2023; 14(9): 1369-1384
Published online Sep 15, 2023. doi: 10.4239/wjd.v14.i9.1369
XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway
Xin-Lin Zhu, Dong-Ying Hu, Zhao-Xiang Zeng, Wei-Wei Jiang, Tian-Yang Chen, Tian-Cheng Chen, Wan-Qing Liao, Wen-Zhi Lei, Wen-Jie Fang, Wei-Hua Pan
Xin-Lin Zhu, Dong-Ying Hu, Wei-Wei Jiang, Tian-Yang Chen, Tian-Cheng Chen, Wan-Qing Liao, Wen-Zhi Lei, Wen-Jie Fang, Wei-Hua Pan, Department of Dermatology, Shanghai Key Laboratory of Medical Mycology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
Zhao-Xiang Zeng, Department of Vascular Surgery, Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 20003, China
Author contributions: Pan WH, Liao WQ, Fang WJ, Lei WZ, and Zhu XL contributed to conceptualization; Zhu XL, Zeng ZX, and Jiang WW contributed to data curation; Zhu XL, Jiang WW, Zeng ZX, Hu DY, Chen TY, Chen TC, Liao WQ, Lei WZ, Fang WJ, and Pan WH contributed to investigation; Zhu XL, Zeng ZX, Jiang WW, Fang WJ, and Pan WH contributed to methodology; Pan WH contributed to project administration; Pan WH, Fang WJ, and Lei WZ contributed to supervision; Zeng ZX, Hu DY, and Zhu XL contributed to visualization; Zhu XL contributed to writing-original draft preparation; Liao WQ, Fang WJ, Pan WH, and Zhu XL contributed to writing-review and editing; Zhu XL, Hu DY, and Zeng ZX contribute equally to this paper.
Supported by the National Natural Science Foundation of China, No. 82272355; and Shanghai Science and Technology Committee, No. 21410750500.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Naval Medical University Medical Ethics Committee (Protocol No: 2020YffiPZ-102).
Conflict-of-interest statement: All the authors have declared no conflict of interest.
Data sharing statement: All data are provided in this study, and raw data can be requested to the corresponding author.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Hua Pan, PhD, Chief Doctor, Department of Dermatology, Shanghai Key Laboratory of Medical Mycology, Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Shanghai 200003, China. panweihua9@sina.com
Received: May 24, 2023
Peer-review started: May 24, 2023
First decision: June 12, 2023
Revised: July 6, 2023
Accepted: August 2, 2023
Article in press: August 2, 2023
Published online: September 15, 2023
Processing time: 112 Days and 10.9 Hours
Core Tip

Core Tip: The role of XB130 in the occurrence and development of diabetic skin ulcers healing is unclear. This study showed that the expression of XB130 was up-regulated in tissues of diabetic skin ulcers and human umbilical vein endothelial cells (HUVECs) stimulated by high glucose. Knockdown of XB130 promote the healing of skin wounds in mice, leading to an accelerated wound healing process and shortened wound healing time and alleviated hyperglycemia-induced cell proliferation inhibition and angiogenic impairment in HUVECs.