Minireviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2023; 14(9): 1334-1340
Published online Sep 15, 2023. doi: 10.4239/wjd.v14.i9.1334
MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation: implications for innovative type 2 diabetes mellitus management
Konstantinos I Papadopoulos, Alexandra Papadopoulou, Tar-Choon Aw
Konstantinos I Papadopoulos, Department of R&D, THAI StemLife, Bangkok 10310, Thailand
Alexandra Papadopoulou, Occupational and Environmental Health Services, Feelgood Lund, Lund 223-63, Skåne, Sweden
Tar-Choon Aw, Department of Laboratory Medicine, Changi General Hospital, Singapore 529889, Singapore, Singapore
Tar-Choon Aw, Department of Medicine, National University of Singapore, Singapore 119228, Singapore, Singapore
Author contributions: Papadopoulos KI conceived and conceptualized the argumentation, designed the layout, drafted the initial manuscript, and reviewed and revised the manuscript; Papadopoulou A performed the literature search, extracted vital information, contributed to the synthesis of the minireview, and reviewed and revised the manuscript; Aw TC coordinated and supervised literature search, made substantial and direct intellectual contributions and critically reviewed the manuscript for important intellectual content; All authors approved the submitted final manuscript and agree to be accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Konstantinos I Papadopoulos, MD, PhD, Chief Physician, Director, Department of R&D, THAI StemLife, 566/3 THAI StemLife bldg., Soi Ramkhamhaeng 39 (Thepleela 1), Prachaouthit Rd., Wangthonglang, Bangkok 10310, Thailand. kostas@thaistemlife.co.th
Received: April 14, 2023
Peer-review started: April 14, 2023
First decision: June 13, 2023
Revised: June 18, 2023
Accepted: July 13, 2023
Article in press: July 13, 2023
Published online: September 15, 2023
Processing time: 151 Days and 22.2 Hours
Core Tip

Core Tip: MicroRNAs (miRNA) are small, non-coding, one-stranded RNA molecules that can target and silence over 60% of human genes thereby effectively regulating huge genetic networks. MiRNAs are abundantly found in every human cell and their production is tightly controlled. They play critical roles in regulating almost every cellular pathway, numerous human diseases, and have been linked to the development of diabetes mellitus (DM) and the regulation of blood pressure. In this minireview, we comment on crucial miR-155 effects in type 2 DM (T2DM). Deeper mechanistical understanding of this miRNA’s permeating action may lead to innovative therapeutic approaches in T2DM.