Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2023; 14(8): 1146-1162
Published online Aug 15, 2023. doi: 10.4239/wjd.v14.i8.1146
Advanced glycation end products: Key mediator and therapeutic target of cardiovascular complications in diabetes
Savita Bansal, Archana Burman, Asok Kumar Tripathi
Savita Bansal, Department of Biochemistry, Institute of Home Sciences, University of Delhi, New Delhi 110016, India
Archana Burman, Department of Biochemistry, Institute of Home Economics, University of Delhi, New Delhi 110016, India
Asok Kumar Tripathi, Department of Biochemistry, University College of Medical Sciences, University of Delhi, New Delhi 110095, India
Author contributions: Bansal S frames the review article; all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Savita Bansal, PhD, Assistant Professor, Department of Biochemistry, Institute of Home Sciences, University of Delhi, Hauz Khas, New Delhi 110016, India. savita.bansal@ihe.du.ac.in
Received: January 29, 2023
Peer-review started: January 29, 2023
First decision: March 1, 2023
Revised: March 21, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: August 15, 2023
Processing time: 193 Days and 22.7 Hours
Core Tip

Core tip: Cardiovascular diseases (CVDs) in type 2 diabetes mellitus impose a clinical and an economic burden on the healthcare system. Early diagnosis of diabetes may prevent its progression to complications and decrease its associated comorbidities. The present manuscript reports the clinical relevance of estimating advanced glycation end products (AGEs) in diabetes. The deleterious effects of AGEs include many important biochemical reactions central to the development and progression of cardiovascular complications in diabetes. Therefore, AGEs are one of the important targets for future diagnosis and prevention of diabetes. The epidemiology of CVD in diabetes, AGEs as a crucial mediator of diabetic CVD, and an overview of different strategies for countering the accumulation of AGEs is discussed along with new therapeutic interventions to ameliorate their effects.