Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2023; 14(7): 995-1012
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.995
Advanced glycation end product signaling and metabolic complications: Dietary approach
Mohammad Idreesh Khan, Fauzia Ashfaq, Abdulrahman A Alsayegh, Alshaimaa Hamouda, Fahmida Khatoon, Tahani Nasser Altamimi, Fahad Saad Alhodieb, Mirza Masroor Ali Beg
Mohammad Idreesh Khan, Fahad Saad Alhodieb, Department of Clinical Nutrition, College of Applied Health Sciences in Ar Rass, Qassim University, Ar Rass 51921, Saudi Arabia
Fauzia Ashfaq, Abdulrahman A Alsayegh, Alshaimaa Hamouda, Clinical Nutrition Department, Applied Medical Sciences College, Jazan University, Jazan 82817, Saudi Arabia
Fahmida Khatoon, Department of Biochemistry, College of Medicine, University of Hail, Hail 2240, Saudi Arabia
Tahani Nasser Altamimi, Department of Family and Community Medicine, College of Medicine, University of Hail, Hail 2240, Saudi Arabia
Mirza Masroor Ali Beg, Faculty of Medicine, Alatoo International University, Bishkek 720048, Kyrgyzstan
Author contributions: Khan MI, Ashfaq F, Alsayegh AA, and Hamouda A helped in writing and reviewing the manuscript; Khatoon F, Altamimi TN, and Alhodieb FS helped in revising the manuscript; Beg MMA contributed to the design, writing, and figures.
Supported by the Deputyship for Research and Innovation, Ministry of Education and Qassim University, Saudi Arabia (Project No. QU-IF-2-2-1-27012).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mirza Masroor Ali Beg, PhD, Associate Professor, Director, Faculty of Medicine, Alatoo International University, 1/8 Ankara Street, Bishkek 720048, Kyrgyzstan. mirzamasroor1986@gmail.com
Received: January 30, 2023
Peer-review started: January 30, 2023
First decision: March 24, 2023
Revised: April 8, 2023
Accepted: April 27, 2023
Article in press: April 27, 2023
Published online: July 15, 2023
Processing time: 163 Days and 14 Hours
Core Tip

Core Tip: All chronic illnesses involve protein, lipid, or nucleic acid modifications, including crosslinked and nondegradable aggregates known as advanced-glycation end products (AGEs). Endogenous AGE formation or dietary AGE uptake can result in additional protein modifications and stimulation of several inflammatory signaling pathways. Many of these systems, however, require additional explanation because they are not entirely obvious. This review summarizes the current evidence regarding dietary sources of AGEs and metabolism related complications associated with AGEs.