Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2023; 14(7): 1049-1056
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1049
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1049
Liver or kidney: Who has the oar in the gluconeogenesis boat and when?
Biswajit Sahoo, Medha Srivastava, Arpit Katiyar, Swasti Tiwari, Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Carolyn Ecelbarger, Department of Medicine, Georgetown University, Washington, DC 20057, United States
Author contributions: Sahoo B, Srivastava M, and Katiyar A reviewed the literature and drafted the manuscript; Sahoo B drew the figure; Ecelbarger C edited the manuscript and figures and proofread the final version for English language; Tiwari S designed and supervised the project and reviewed and edited the manuscript; All authors contributed to the article and approved the submitted version.
Supported by the Indian Council of Medical Research grant to S.T , No. Coord/7 (1)/CARE-KD/2018/NCD-II .
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Swasti Tiwari, PhD, Professor, Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. tiwari.pgi@gmail.com
Received: January 16, 2023
Peer-review started: January 16, 2023
First decision: February 8, 2023
Revised: February 20, 2023
Accepted: April 11, 2023
Article in press: April 11, 2023
Published online: July 15, 2023
Peer-review started: January 16, 2023
First decision: February 8, 2023
Revised: February 20, 2023
Accepted: April 11, 2023
Article in press: April 11, 2023
Published online: July 15, 2023
Core Tip
Core Tip: The liver and kidneys have an essential role in regulating glucose homeostasis through gluconeogenesis. However, the two tissues prefer different substrates. The contribution of kidney vs liver gluconeogenesis may vary under certain physiological and pathological conditions. However, increased gluconeogenesis in the liver and kidneys contributes to hyperglycemia in the pathogenic stage of type 2 diabetes mellitus. While in the case of metabolic acidosis, which develops in response to diabetes, gluconeogenesis induction occurs exclusively in the kidneys. Nevertheless, the two organs often compensate for each other by inter-organ coordination to maintain glucose and energy homeostasis.