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World J Diabetes. Jun 15, 2023; 14(6): 808-819
Published online Jun 15, 2023. doi: 10.4239/wjd.v14.i6.808
Effect of resveratrol in gestational diabetes mellitus and its complications
Hui-Zhong Ma, Yuan Chen, Hao-Hao Guo, Jing Wang, Xiu-Lan Xin, Yan-Cheng Li, Yu-Feng Liu
Hui-Zhong Ma, Yuan Chen, Hao-Hao Guo, Jing Wang, School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, Liaoning Province, China
Xiu-Lan Xin, College of Bioengineering, Beijing Polytechnic, Beijing 100176, China
Yan-Cheng Li, Department of Epidemiology, University of Florida, Gainesville, FL 32608, United States
Yu-Feng Liu, School of Pharmaceutical Sciences, Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning Province, Liaoning University, Shenyang 110036, Liaoning Province, China
Author contributions: Ma HZ and Liu YF designed the review and wrote the manuscript; Chen Y and Guo HH conducted data collection and selection; Wang J designed the table and edited the manuscript; Xin XL and Li YC performed the data analyses; All authors read and approved the final manuscript.
Supported by the Innovative Talents Support Program of Liaoning Province, No. LR2018047; the Natural Science Foundation of Liaoning Province, No. 2021-MS-150; the Support Plan for the Construction of High-level Teachers in Beijing Municipal Colleges and Universities, No. CIT&TCD 201904047; and the Research on National Reference Material and Product Development of Natural Products in Beijing Polytechnic, No. SG030801.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Feng Liu, PhD, Professor, School of Pharmaceutical Sciences, Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning Province, Liaoning University, No. 66 Chongshan Mid-Road, Huanggu District, Shenyang 110036, Liaoning Province, China. liuyufeng@bjmu.edu.cn
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: February 8, 2023
Revised: February 23, 2023
Accepted: April 20, 2023
Article in press: April 20, 2023
Published online: June 15, 2023
Processing time: 169 Days and 6.1 Hours
Core Tip

Core Tip: Resveratrol (RSV) is a natural polyphenol compound. Previous studies have shown that RSV has a potential beneficial effect in complex pregnancy, including improving the indicators of diabetes and improving pregnancy diabetes syndrome. This article reviews the molecular targets and signaling pathways of RSV including AMP-activated protein kinase, mitogen-activated protein kinases, silent information regulator sirtuin 1, miR-23a-3p, reactive oxygen species, potassium channels and CX3C chemokine ligand 1, and the effect of RSV on gestational diabetes mellitus and its complications. It also provides more options and possibilities for further research on medication of gestational diabetes.