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World J Diabetes. May 15, 2023; 14(5): 528-538
Published online May 15, 2023. doi: 10.4239/wjd.v14.i5.528
What, why and how to monitor blood glucose in critically ill patients
Deven Juneja, Desh Deepak, Prashant Nasa
Deven Juneja, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India
Desh Deepak, Department of Critical Care, King's College Hospital, Dubai 340901, United Arab Emirates
Prashant Nasa, Department of Critical Care, NMC Speciality Hospital, Dubai 7832, United Arab Emirates
Prashant Nasa, Department of Critical Care, College of Medicine and Health Sciences, Al Ain 15551, United Arab Emirates
Author contributions: Juneja D and Deepak D performed the majority of the writing, prepared the tables and performed data accusation; Nasa P provided the input in writing the paper and reviewed the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deven Juneja, DNB, FCCP, MBBS, Director, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, 1 Press Enclave Road, New Delhi 110017, India. devenjuneja@gmail.com
Received: November 18, 2022
Peer-review started: November 18, 2022
First decision: January 17, 2023
Revised: January 17, 2023
Accepted: March 7, 2023
Article in press: March 7, 2023
Published online: May 15, 2023
Processing time: 177 Days and 23.6 Hours
Core Tip

Core Tip: Blood glucose (BG) monitoring is a vital component of critical care management. Even non-diabetic critically ill patients are prone to glycemic fluctuations necessitating frequent blood sampling and BG monitoring. Multiple medications, presence of underlying comorbidities and organ dysfunctions, and rapidly changing patient condition make BG control challenging in critically ill patients. Even the commonly used capillary blood sampling for BG monitoring may not be reliable in these patients. In addition to the established parameters of hypoglycemia and hyperglycemia, newer glycemic indices like glycemic variability and time in target range have also been recognized to affect outcomes of critically ill patients, further complicating BG monitoring. Devices for continuous glucose monitoring are also being increasingly tested in these patients, and their use in conjunction with artificial intelligence-based devices may provide a solution to comprehensive glucose control in the future.