Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2023; 14(3): 299-312
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.299
Glucose metabolism continuous deteriorating in male patients with human immunodeficiency virus accepted antiretroviral therapy for 156 weeks
Da-Feng Liu, Xin-Yi Zhang, Rui-Feng Zhou, Lin Cai, Dong-Mei Yan, Li-Juan Lan, Sheng-Hua He, Hong Tang
Da-Feng Liu, Li-Juan Lan, Department of Internal Medicine, Public Health and Clinical Center of Chengdu, Chengdu 610061, Sichuan Province, China
Xin-Yi Zhang, Department of Endocrinology and Metabolism, Sichuan University West China Hoapital, Chengdu 610041, Sichuan Province, China
Rui-Feng Zhou, Lin Cai, Dong-Mei Yan, Sheng-Hua He, Department of Infectious Disease, Public Health and Clinical Center of Chengdu, Chengdu 610061, Sichuan Province, China
Hong Tang, Center of Infectious Disease, Sichuan University West China Hoapital, Chengdu 610041, Sichuan Province, China
Author contributions: Liu DF, Zhang XY, Zhou RF, Cai L, Yan DM, Lan LJ, He SH and Tang H contributed concept and design; Liu DF, Zhang XY, Zhou RF, Cai L, Yan DM and Lan LJ contributed data acquisition; Liu DF, Zhang XY, Zhou RF, Cai L, Yan DM and Lan LJ contributed data analysis and interpretation; Liu DF, Zhang XY, Zhou RF, Cai L, Yan DM and Lan LJ contributed drafting of the manuscript; Liu DF, Zhou RF, Cai L, Yan DM, Lan LJ, He SH and Tang H contributed administrative, technical, or material support; He SH and Tang H contributed study supervision.
Supported by The Twelfth Five-Year Project on Tackling Key Problems of National Science and Technology, No. 2012ZX10001-003; Sichuan Province Health Commission, No. 130430 and No. 17PJ070; and Chengdu Municipal Health Commission, No. 2019079.
Institutional review board statement: The study was approved by the hospital ethics committee of the Public and Health Clinic Centre of Chengdu (PJ-K2012-012-01).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data, models, or code generated or used during the study are available from the corresponding author by request: Liu DF, E-mail: liudf312@126.com.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Da-Feng Liu, MD, Chief Physician, Department of Internal Medicine, Public Health and Clinical Center of Chengdu, No. 377 Jingming Road, Jinjiang District, Chengdu 610061, Sichuan Province, China. ldf312@126.com
Received: October 1, 2022
Peer-review started: October 1, 2022
First decision: December 12, 2022
Revised: December 21, 2022
Accepted: February 27, 2023
Article in press: February 27, 2023
Published online: March 15, 2023
Processing time: 165 Days and 8.1 Hours
Core Tip

Core Tip: To our knowledge, this prospective cohort study is the first to report the long-term dynamic effects of the tenofovir plus lamivudine plus efavirenz regimen and the baseline CD4+ T cell count on glucose metabolism in male patients living with human immunodeficiency virus. The result showed that gradual increases in the fasting plasma glucose, impaired fasting glucose rate and glycosylated hemoglobin, due to insulin resistance but rather to significantly reduced islet β cell function, regardless of glucose metabolism disorder or not at baseline. Baseline CD4+ T cell count could impact on fasting plasma glucose and homeostasis model assessment of β cell function.