Clinical Trials Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2023; 14(3): 279-289
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.279
Postprandial glucagon-like peptide 1 secretion is associated with urinary albumin excretion in newly diagnosed type 2 diabetes patients
Lu-Lu Song, Na Wang, Jin-Ping Zhang, Li-Ping Yu, Xiao-Ping Chen, Bo Zhang, Wen-Ying Yang
Lu-Lu Song, Na Wang, Jin-Ping Zhang, Li-Ping Yu, Xiao-Ping Chen, Bo Zhang, Wen-Ying Yang, Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Song LL analyzed the data the data and drafted the manuscript; Zhang JP and Wang N collected the data and performed the literature review; Yu LP provides ideas and commentary in the process of writing the article; Chen XP and Zhang B coordinated the implementation of the study; Yang WY was the principal investigator of the study; and all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved China-Japan Friendship Hospital Institutional Review Board (Approval No. 2008-23).
Clinical trial registration statement: This trial was registered at ChiCTR (registration: No. ChiCTR-TRC-08000231).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Ying Yang, MD, Professor, Department of Endocrinology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing 100029, China, ywy_1010@163.com
Received: October 27, 2022
Peer-review started: October 27, 2022
First decision: December 12, 2022
Revised: December 21, 2022
Accepted: February 16, 2023
Article in press: February 16, 2023
Published online: March 15, 2023
Processing time: 139 Days and 14 Hours
Core Tip

Core Tip: The association between the microalbuminuria and glucagon-like peptide 1 (GLP-1) response after a standard meal load in newly diagnosed Chinese type 2 diabetes mellitus patients was identified. Patients with microalbuminuria showed lower postprandial GLP-1 levels than those without microalbuminuria. The prevalence of microalbuminuria decreased with increasing quartiles of 30 min and 120 min and area under the curve for active GLP-1 levels after a standard meal. The highlights of our study are that the patients were newly diagnosed, which excluded the influence of glucose-lowering therapies. Furthermore, we assessed the fasting and postprandial GLP-1 levels in response to a standard meal, not oral glucose. Third, the GLP-1 determined in our study was active GLP-1, not total GLP-1.