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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2023; 14(2): 62-75
Published online Feb 15, 2023. doi: 10.4239/wjd.v14.i2.62
Published online Feb 15, 2023. doi: 10.4239/wjd.v14.i2.62
Modulatory effect of caffeic acid in alleviating diabetes and associated complications
Risha Ganguly, Shiv Vardan Singh, Kritika Jaiswal, Ramesh Kumar, Abhay K Pandey, Department of Biochemistry, University of Allahabad, Allahabad (Prayagraj) 211002, India
Author contributions: Pandey AK conceptualized the idea; Ganguly R, Singh SV, Jaiswal K, and Kumar R performed the literature search; Ganguly R and Singh SV wrote the first draft of the manuscript and validated the references; Pandey AK critically reviewed and revised the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abhay K Pandey, PhD, Professor, Department of Biochemistry, University of Allahabad, University Road, Allahabad (Prayagraj) 211002, India.
Received: August 28, 2022
Peer-review started: August 28, 2022
First decision: October 21, 2022
Revised: November 4, 2022
Accepted: December 13, 2022
Article in press: December 13, 2022
Published online: February 15, 2023
Processing time: 169 Days and 17.7 Hours
Peer-review started: August 28, 2022
First decision: October 21, 2022
Revised: November 4, 2022
Accepted: December 13, 2022
Article in press: December 13, 2022
Published online: February 15, 2023
Processing time: 169 Days and 17.7 Hours
Core Tip
Core Tip: Diabetes mellitus has emerged as one of the most common metabolic disorders worldwide which can lead to other complications such as retinopathy, nephropathy, neuropathy, and foot ulcers. Free radical-induced oxidative stress is one of the primary causes of diabetes. Caffeic acid (CA) is a natural polyphenol obtained from various fruits and vegetables. CA and its derivatives act as an antioxidant and regulate the signaling pathways involved in lipid and carbohydrate metabolism. CA also exerts anti-diabetic effects by modulation of inflammatory cytokines and transcription factors.