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World J Diabetes. Nov 15, 2023; 14(11): 1621-1631
Published online Nov 15, 2023. doi: 10.4239/wjd.v14.i11.1621
Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development
Yi-Chen Guo, Hao-Di Cao, Xiao-Fen Lian, Pei-Xian Wu, Fan Zhang, Hua Zhang, Dong-Hui Lu
Yi-Chen Guo, Xiao-Fen Lian, Pei-Xian Wu, Fan Zhang, Dong-Hui Lu, Department of Endo-crinology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Yi-Chen Guo, Hao-Di Cao, Hua Zhang, Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
Author contributions: Guo YC and Cao HD contributed equally to this work; Guo YC, Cao HD, Lian XF, Wu PX, Zhang F, Zhang H, and Lu DH designed the research; Cao HD and Lian XF contributed analytic tools and specifically visualization; Guo YC analyzed the data and wrote the manuscript; Wu PX, Zhang F, Zhang H, and Lu DH edited and reviewed the manuscript; and all authors have read and approve the final manuscript.
Supported by the Shenzhen Science and Technology Innovation Committee Projects, No. JCYJ20170816105416349; Shenzhen High-level Hospital Construction Fund; and Shenzhen Key Medical Discipline Construction Fund, No. SZXK010.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Hui Lu, MD, Chief Physician, Department of Endocrinology, Peking University Shenzhen Hospital, No. 1120 Lianhua Road, Futian District, Shenzhen 518036, Guangdong Province, China. ludongh@sina.com
Received: July 12, 2023
Peer-review started: July 12, 2023
First decision: August 10, 2023
Revised: August 26, 2023
Accepted: September 27, 2023
Article in press: September 27, 2023
Published online: November 15, 2023
Processing time: 124 Days and 18.6 Hours
Core Tip

Core Tip: Non-coding RNA (ncRNA) and epigenetic regulation play crucial roles in the pathogenesis of diabetes mellitus complicated by obesity. Identification of the involvement of ncRNA and epigenetic regulation in the pathogenesis of diabetes with obesity has opened new avenues. Targeting these mechanisms with small molecules or RNA-based therapies may provide a more precise and effective approach to diabetes treatment than traditional therapies.