Prospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2022; 13(7): 566-580
Published online Jul 15, 2022. doi: 10.4239/wjd.v13.i7.566
Relationship between quality of life and adolescent glycolipid metabolism disorder: A cohort study
Xiao-Hua Liang, Yang-Ling Ren, Xiao-Yue Liang, Jing-Yu Chen, Ping Qu, Xian Tang
Xiao-Hua Liang, Yang-Ling Ren, Xiao-Yue Liang, Ping Qu, Xian Tang, Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China
Jing-Yu Chen, Ultrasound Department of Children’s Hospital of Chongqing Medical University, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
Author contributions: Liang XH conceived of and designed the study; Qu P and Chen JY participated in the acquisition of the data; Liang XH analysed the data; Liang XH, Ren YL, and Liang XY drafted and revised the manuscript; all authors critically reviewed and approved the final paper.
Supported by Intelligent Medicine Research Project of Chongqing Medical University, No. ZHYX202109; The Major Health Project of Chongqing Science and Technology Bureau, No. CSTC2021jscx-gksb-N0001; Research and Innovation Team of Chongqing Medical University, No. W0088; Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau, No. 2020MSXM062; National Key Research and Development Project of the Ministry of Science and Technology of the People's Republic of China, No. 2017YFC0211705; and Young Scientists Fund Program of the National Natural Science Foundation of China, No. 81502826.
Institutional review board statement: The study was reviewed and approved by the Chongqing Jiulongpo District Center for Disease Control and Prevention Institutional Review Board, No. 2013-006.
Clinical trial registration statement: This study is registered at ChiCTR. The registration identification number is ChiCTR2100048861.
Informed consent statement: Informed consent was obtained from all patients for inclusion in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Anonymised participant data will be shared after approval by the corresponding author, following a reasonable submitted request. Data are available from Xiao-Hua Liang (Clinical Epidemiology and Biostatistics Department, Children’s Hospital of Chongqing Medical University, No.136 2nd Zhongshan Road, Yuzhong District, Chongqing, China, 400016; Email: xiaohualiang@hospital.cqmu.edu.cn or liangxiaohua666@sina.com).
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Hua Liang, MD, PhD, Associate Research Scientist, Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, No. 136 2nd Street, Yuzhong District, Chongqing 400016, China. xiaohualiang@hospital.cqmu.edu.cn
Received: December 20, 2021
Peer-review started: December 20, 2021
First decision: April 18, 2022
Revised: April 29, 2022
Accepted: June 20, 2022
Article in press: June 20, 2022
Published online: July 15, 2022
Processing time: 203 Days and 5.6 Hours
Core Tip

Core Tip: Persistent abnormalities of glucose and lipid metabolism in childhood have a well-established association with adulthood cardiovascular diseases. Previous conclusions about the association between quality of life (QoL) and glycolipid metabolism disorder (GLMD) were almost all based on adults with type 2 diabetes or dyslipidaemia, whereas there is limited evidence for the association between QoL and GLMD in healthy children and adolescents. This study found that a poor QoL score was associated with increased insulin, triglyceride, and IR levels, and the association was more significant in males than in females. In addition, seven domains, four factors, and total QoL score were negatively associated with abnormalities in glucose and lipid metabolism. Measures to improve the QoL of adolescents are essential to reduce the prevalence of GLMD.