Observational Study
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World J Diabetes. Jul 15, 2022; 13(7): 553-565
Published online Jul 15, 2022. doi: 10.4239/wjd.v13.i7.553
Factors associated with trabecular bone score in postmenopausal women with type 2 diabetes and normal bone mineral density
Olga N Fazullina, Anton I Korbut, Vadim V Klimontov
Olga N Fazullina, Anton I Korbut, Vadim V Klimontov, Laboratory of Endocrinology, Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630060, Russia
Author contributions: Klimontov VV contributed to study conception and design, data analysis and interpretation; Fazullina ON and Korbut AI collected the data and performed data analysis and interpretation; Fazullina ON and Klimontov VV wrote the article; all authors approved the final version of the manuscript.
Institutional review board statement: The study protocol was approved by the Ethical Committee of the RICEL - Branch of IC&G SB RAS (protocol N. 104 from 20 December 2014).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vadim V Klimontov, DSc, MD, PhD, Professor, Laboratory of Endocrinology, Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Timakov Street 2, Novosibirsk 630060, Russia. klimontov@mail.ru
Received: February 15, 2022
Peer-review started: February 15, 2022
First decision: April 17, 2022
Revised: May 2, 2022
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: July 15, 2022
Processing time: 145 Days and 15.1 Hours
Core Tip

Core Tip: In this study, we assessed the impact of a wide range of general and diabetes-related parameters on trabecular bone score (TBS) in postmenopausal women with type 2 diabetes (T2D) and normal bone mineral density (BMD). A decrease in TBS was revealed in 44.8% of study participants. These data indicate that a substantial proportion of postmenopausal women with T2D and normal BMD may have impaired bone microarchitecture. Greater height and central adiposity turned out to be the risk factors for decreased TBS in these women.