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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2022; 13(7): 498-520
Published online Jul 15, 2022. doi: 10.4239/wjd.v13.i7.498
Published online Jul 15, 2022. doi: 10.4239/wjd.v13.i7.498
Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease
María M Adeva-Andany, Natalia Carneiro-Freire, Nephrology, Hospital Juan Cardona, Ferrol 15406, Spain
Author contributions: Adeva-Andany MM conceived and designed the review, performed the literature search and wrote the original draft of the manuscript; Carneiro-Freire N contributed to the writing and revision of intellectual content; both authors participated in the final version of the manuscript.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: María M Adeva-Andany, MD, PhD, Consultant Physician-Scientist, Nephrology, Hospital Juan Cardona, Pardo Bazán x/n, Ferrol 15406, Spain.
Received: February 1, 2022
Peer-review started: February 1, 2022
First decision: April 18, 2022
Revised: April 19, 2022
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: July 15, 2022
Processing time: 159 Days and 14.7 Hours
Peer-review started: February 1, 2022
First decision: April 18, 2022
Revised: April 19, 2022
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: July 15, 2022
Processing time: 159 Days and 14.7 Hours
Core Tip
Core Tip: Diabetic kidney disease is associated with profound disturbance in glomerular extracellular matrix (ECM). Understanding the mechanisms that regulate glomerular ECM synthesis and repair may contribute to design therapeutic strategies that improve clinical outcomes. The cytoskeleton inside the foot processes of podocytes is connected to the glomerular basement membrane (GBM) via associated proteins. There is a reciprocal interaction between the cellular cytoskeleton and the extracellular tissue that contribute to regulate ECM composition. Loss of anchor points in the GBM may lead to podocyte detachment. Likewise, alterations in the podocyte cytoskeleton may unfasten the cell and impair the filtration barrier.