Venkataseshan J, Viswanathan P. Hyperbaric oxygen therapy and chemokine administration - a combination with potential therapeutic value for treating diabetic wounds. World J Diabetes 2022; 13(12): 1122-1130 [PMID: 36578873 DOI: 10.4239/wjd.v13.i12.1122]
Corresponding Author of This Article
Pragasam Viswanathan, MSc, PhD, Academic Editor, Professor, School of Bio Sciences and Technology, Vellore Institute of Technology, #412B, Renal Research Lab, Pearl Research Park, Vellore 632014, Tamil Nadu, India. pragasam.v@vit.ac.in
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Dec 15, 2022; 13(12): 1122-1130 Published online Dec 15, 2022. doi: 10.4239/wjd.v13.i12.1122
Hyperbaric oxygen therapy and chemokine administration - a combination with potential therapeutic value for treating diabetic wounds
Jagannathan Venkataseshan, Pragasam Viswanathan
Jagannathan Venkataseshan, Pragasam Viswanathan, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India
Author contributions: Jaganathan V and Pragasam V designed and wrote the manuscript; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pragasam Viswanathan, MSc, PhD, Academic Editor, Professor, School of Bio Sciences and Technology, Vellore Institute of Technology, #412B, Renal Research Lab, Pearl Research Park, Vellore 632014, Tamil Nadu, India. pragasam.v@vit.ac.in
Received: August 22, 2022 Peer-review started: August 22, 2022 First decision: September 12, 2022 Revised: September 30, 2022 Accepted: November 4, 2022 Article in press: November 4, 2022 Published online: December 15, 2022 Processing time: 115 Days and 1.6 Hours
Core Tip
Core Tip: Diabetes induces slow or non-healing of wounds, increasing the risk of developing infection and other complications. Proper management of blood sugar levels is essential to improve the overall health. Hyperbaric oxygen therapy (HBOT) enhances the efficacy of wound healing rate in chronic diabetic foot ulcer patients. However, the systemic and meta-analysis data contradicts in cases associated with ischemic wounds. Also, the uncordial functioning of effector cells due to the interrupted signaling pathway involving chemokines and related growth factors worsens the condition of wound healing to a greater extent. Thus, a combinatorial approach of HBOT and chemokine administration could have potential therapeutic value for treating diabetic wounds with the existing clinical protocol.
