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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2021; 12(8): 1267-1281
Published online Aug 15, 2021. doi: 10.4239/wjd.v12.i8.1267
Published online Aug 15, 2021. doi: 10.4239/wjd.v12.i8.1267
Decabromodiphenyl ether causes insulin resistance and glucose and lipid metabolism disorders in mice
Ayiguli Alimu, Haiqiemuhan Abudureman, Mei-Yan Li, Jia-Sui Wang, Zao-Ling Liu, Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi 0991, Xinjiang Uygur Autonomous Region, China
Yong-Zhi Wang, Department of Public Health, Xinjiang Second Medical College, Cremayi 834000, Xinjiang Uygur Autonomous Region, China
Author contributions: Liu ZL participated in research design; Alimu A, Abudureman H, Wang ZW, Li MY, and Wang JS conducted the experiments; Alimu A and Liu ZL performed data analysis; Alimu A and Liu ZL wrote or edited the manuscript.
Supported by National Natural Science Foundation of China , No. 81760596 ; and Natural Science Foundation of Xinjiang Uygur Autonomous Region , No. 2019D01C209 .
Institutional review board statement: Our research protocol was evaluated and approved by the Ethics Review Committee of the First Affiliated Hospital of Xinjiang Medical University (No. 20170214-107).
Institutional animal care and use committee statement: The animals were handled in accordance with the Guide for the Care and Use of Laboratory Animals.
Conflict-of-interest statement: No conflict of interest exits in the submission of this manuscript, and the manuscript has been approved by all authors for publication.
Data sharing statement: No other data available.
ARRIVE guidelines statement: I has read the "ARRIVE Guidelines" and has compiled and revised the manuscript according to the "ARRIVE Guidelines".
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zao-Ling Liu, PhD, Professor, Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, No. 393 Xinyi Road, Xinshi District, Urumqi 0991, Xinjiang Uygur Autonomous Region, China. 136497460@qq.com
Received: December 18, 2020
Peer-review started: December 18, 2020
First decision: May 3, 2021
Revised: May 15, 2021
Accepted: June 25, 2021
Article in press: June 25, 2021
Published online: August 15, 2021
Processing time: 233 Days and 5.2 Hours
Peer-review started: December 18, 2020
First decision: May 3, 2021
Revised: May 15, 2021
Accepted: June 25, 2021
Article in press: June 25, 2021
Published online: August 15, 2021
Processing time: 233 Days and 5.2 Hours
Core Tip
Core Tip: Decabromodiphenyl ether (BDE-209) may be an environmental risk factor leading to obesity. There are limited literature reports on the correlation between BDE-209 and obesity. This type of research began with animal experiments, and the results showed that BDE-209 affects animal body weight, but the direction of the effect is not consistent. This study found that BDE-209 increased the body weight and body fat and liver tissue weight in mice, which may be related to the activation of peroxisome proliferators activated receptor-γ receptor and the abnormal differentiation of adipocytes. In obese patients, proinflammatory cytokines and interleukin-6 can cause insulin resistance through a variety of mechanisms.