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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2021; 12(8): 1164-1186
Published online Aug 15, 2021. doi: 10.4239/wjd.v12.i8.1164
Published online Aug 15, 2021. doi: 10.4239/wjd.v12.i8.1164
Current progress in metabolomics of gestational diabetes mellitus
Qian-Yi Wang, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 21000, Jiangsu Province, China
Liang-Hui You, Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing 21000, Jiangsu Province, China
Lan-Lan Xiang, Yi-Tian Zhu, Yu Zeng, Department of Clinical Laboratory, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing 21000, Jiangsu Province, China
Author contributions: Wang QY drafted the initial manuscript and prepared the figure; You LH and Xiang LL searched the literature and provided further editing and comments; Zhu YT participated in the discussion and provided further editing and comments; Zeng Y revised the manuscript and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China , No. 81870546 ; and the Nanjing Medical Science and Technique Development Foundation , No. YKK17177 .
Conflict-of-interest statement: The authors declare no conflicts of interest for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Zeng, PhD, Professor, Department of Clinical Laboratory, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), No. 123 Tianfei Lane, Mochou Road, Qinhuan District, Nanjing 21000, Jiangsu Province, China. zengyu@njmu.edu.cn
Received: February 8, 2021
Peer-review started: February 8, 2021
First decision: April 20, 2021
Revised: May 20, 2021
Accepted: July 7, 2021
Article in press: July 7, 2021
Published online: August 15, 2021
Processing time: 182 Days and 1.3 Hours
Peer-review started: February 8, 2021
First decision: April 20, 2021
Revised: May 20, 2021
Accepted: July 7, 2021
Article in press: July 7, 2021
Published online: August 15, 2021
Processing time: 182 Days and 1.3 Hours
Core Tip
Core Tip: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders of pregnancy. As a metabolic disease, GDM is well suited to metabolomics study, which can monitor the changes in small molecular metabolites induced by maternal stimuli or perturbation in real time. This review provides comprehensive documentation of metabolomics research methods and techniques as well as the current progress in GDM research. We anticipate that the review will contribute to identifying gaps in the current knowledge or metabolomics technology, provide evidence-based information, and inform future research directions in GDM.