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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2021; 12(7): 997-1009
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.997
Mechanisms of altered bone remodeling in children with type 1 diabetes
Giacomina Brunetti, Gabriele D'Amato, Stefania De Santis, Maria Grano, Maria Felicia Faienza
Giacomina Brunetti, Department of Biosciences, Biotechnologies and Biopharmaceutics, University "A. Moro" of Bari, Bari 70125, Italy
Gabriele D'Amato, Department of Women’s and Children’s Health, ASL Bari, Neonatal Intensive Care Unit, Di Venere Hospital, Bari 70124, Italy
Stefania De Santis, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari 70126, Italy
Maria Grano, Department of Emergency and Organ Transplantation, Univ Bari, Bari 70124, Italy
Maria Felicia Faienza, Department of Biomedical Sciences and Human Oncology, Pediatric Unit, University "A.Moro", Bari 70124, Italy
Author contributions: Faienza MF and Brunetti G equally contributed to this paper with conception and design of the article; Faienza MF drafted and revised the paper; D'Amato G and De Santis S performed literature review; Grano M critically revised the final version.
Conflict-of-interest statement: No potential conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giacomina Brunetti, PhD, Academic Research, Department of Biosciences, Biotechnologies and Biopharmaceutics, University "A. Moro" of Bari, Via Orabona 4, Bari 70125, Italy. giacomina.brunetti@uniba.it
Received: January 29, 2021
Peer-review started: January 29, 2021
First decision: March 1, 2021
Revised: March 17, 2021
Accepted: May 22, 2021
Article in press: May 22, 2021
Published online: July 15, 2021
Processing time: 163 Days and 19.2 Hours
Core Tip

Core Tip: Bone fragility is a well-known complication related to type 1 diabetes mellitus, and it can manifest from the disease onset, already in childhood. The mechanisms underlying this relationship, and the precise role of metabolic control in preventing bone impairment, are not yet fully understood. Future studies are needed to clarify better the factors responsible for bone damage in diabetic subjects, and to identify strategies for avoiding and managing osteopenia/osteoporosis in these subjects.