Role of interferons in diabetic retinopathy

doi:10.4239/wjd.v12.i7.939

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2021; 12(7): 939-953
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.939

Role of interferons in diabetic retinopathy

Bing-Yan Li, Wei Tan, Jing-Ling Zou, Yan He, Shigeo Yoshida, Bing Jiang, Ye-Di Zhou

Bing-Yan Li, Wei Tan, Jing-Ling Zou, Yan He, Bing Jiang, Ye-Di Zhou, Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China

Bing-Yan Li, Wei Tan, Jing-Ling Zou, Yan He, Bing Jiang, Ye-Di Zhou, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China

Shigeo Yoshida, Department of Ophthalmology, Kurume University School of Medicine, Kurume 830-0011, Fukuoka, Japan

Author contributions: Zhou YD conceived and designed the study; Li BY wrote the majority of the manuscript and prepared the tables; all authors checked the references and approved the final version of the manuscript.

Supported by National Natural Science Foundation of China, No. 81800855 and No. 82070967; and Natural Science Foundation of Hunan Province, No. 2018JJ3765.

Conflict-of-interest statement: The authors declare that no competing interest exists.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ye-Di Zhou, MD, PhD, Associate Professor, Department of Ophthalmology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. zhouyedi@csu.edu.cn

Received: January 20, 2021
Peer-review started: January 20, 2021
First decision: April 6, 2021
Revised: April 15, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: July 15, 2021
Processing time: 172 Days and 16.8 Hours

Core Tip

Core Tip: Diabetic retinopathy (DR) is one of the microvascular complications of diabetes mellitus and seriously threatens the eyesight of the working-age population. Inflammation and inflammatory cytokines are closely related with its pathological mechanisms. Here we discuss the roles of interferons in DR, mainly from the pathogenesis and clinical applications.