Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2021; 12(7): 1116-1130
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.1116
Expression and role of P-element-induced wimpy testis-interacting RNA in diabetic-retinopathy in mice
Yong Yu, Kai-Ming Ren, Xiao-Long Chen
Yong Yu, Xiao-Long Chen, Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Kai-Ming Ren, Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Yu Y and Ren KM designed this study, conducted the experimental analysis, and wrote the manuscript; Chen XL revised the manuscript; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81570866.
Institutional animal care and use committee statement: The study was reviewed and approved by the Institutional Review Board of Shengjing Hospital of China Medical University (Approval No. 2020PS078K).
Conflict-of-interest statement: No potential conflicts of interest relevant to this article are reported.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Long Chen, MD, Chief Doctor, Surgeon, Department of Ophthalmology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Shenyang 110004, Liaoning Province, China. chenxl@sj-hospital.org
Received: March 2, 2021
Peer-review started: March 2, 2021
First decision: April 6, 2021
Revised: April 11, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: July 15, 2021
Processing time: 132 Days and 1.6 Hours
Core Tip

Core Tip: As one of the major microvascular complications of diabetes, diabetic retinopathy is the leading cause of blindness in the working age population. In the diabetic retinopathy model, the abnormal expression of P-element-induced wimpy testis-interacting RNAs (piRNAs) are involved in angiogenesis and cell proliferation pathways, suggesting that piRNAs have a certain regulatory function in diabetic retinopathy.