Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2021; 12(7): 1057-1069
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.1057
Comprehensive overview of human serum albumin glycation in diabetes mellitus
Hong-Yan Qiu, Ning-Ning Hou, Jun-Feng Shi, Yong-Ping Liu, Cheng-Xia Kan, Fang Han, Xiao-Dong Sun
Hong-Yan Qiu, Ning-Ning Hou, Jun-Feng Shi, Yong-Ping Liu, Cheng-Xia Kan, Xiao-Dong Sun, Department of Endocrinology, The Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Fang Han, Department of Pathology, The Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Author contributions: Qiu HY and Hou NN were responsible for conceptualization, methodology, data curation, and original draft preparation; Shi JF, Liu YP, Kan CX, and Han F were responsible for data curation and investigation; Sun XD was responsible for supervision, manuscript writing and editing, and funding acquisition.
Supported by the National Natural Science Foundation of China, No. 81870593; Natural Science Foundation of Shandong Province of China, No. ZR2020MH106; and Medical Health Science and Technology Project of Shandong Province, No. 202003060400.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Dong Sun, PhD, Professor, Department of Endocrinology, The Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Weifang 261031, Shandong Province, China. sxdfriend@sina.com
Received: March 16, 2021
Peer-review started: March 16, 2021
First decision: May 3, 2021
Revised: May 6, 2021
Accepted: June 4, 2021
Article in press: June 4, 2021
Published online: July 15, 2021
Processing time: 118 Days and 2.5 Hours
Core Tip

Core Tip: In the case of hyperglycemia state, the glycation level of albumin in plasma is significantly increased, which alters the structure and function of albumin. Herein we review the different glycation sites and functional changes of glycated albumin, and discuss the relationship between albumin glycation and diabetes complications. The potential application value of glycated albumin in clinical is also discussed.