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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2021; 12(12): 2119-2129
Published online Dec 15, 2021. doi: 10.4239/wjd.v12.i12.2119
Published online Dec 15, 2021. doi: 10.4239/wjd.v12.i12.2119
Skeletal muscle loss is associated with diabetes in middle-aged and older Chinese men without non-alcoholic fatty liver disease
Ling-Yan Chen, Yu Hu, Hui Ma, Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Ming-Feng Xia, Xin Gao, Huan-Dong Lin, Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Li Wu, Qian Li, Fudan Institute for Metabolic Diseases, Shanghai 200032, China
Author contributions: Chen LY did the study design and literature research, wrote the manuscript, and made critical editing; Chen LY and Lin HD made definition of intellectual content and did data analysis; Chen LY, Xia MF, Wu L, Li Q, Hu Y, Ma H, Gao X, and Lin HD participated in the data acquisition and clinical study; Gao X and Lin HD contributed to study concept and did the critical review and editing of the manuscript; Gao X was the guarantor of integrity of the entire study; Lin HD contributed to statistical analysis; all authors approved the final draft of the manuscript and agreed to submit it for publication.
Supported by the National Key Basic Research Program of China , No. 2012CB524906 and No. 2011CB504004 ; the Shanghai Municipal Health Bureau Foundation , No. 12GWZX0103 ; and the Science and Technology Commission of Shanghai Municipality , No. 10411956400 .
Institutional review board statement: The present study was approved by the Ethics Committee of Zhongshan Hospital of Fudan University (No. 2008-119). The research was carried out in accordance with the World Medical Association Declaration of Helsinki.
Informed consent statement: All participants provided written informed consent before their inclusion in the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The related dataset that do not identify participants’ privacy can be available from the corresponding author at linhuandong_endo@163.com
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huan-Dong Lin, MD, Associate Professor, Chief Doctor, Department of Endocrinology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. linhuandong_endo@163.com
Received: July 2, 2021
Peer-review started: July 2, 2021
First decision: July 15, 2021
Revised: August 5, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 15, 2021
Processing time: 166 Days and 20.9 Hours
Peer-review started: July 2, 2021
First decision: July 15, 2021
Revised: August 5, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 15, 2021
Processing time: 166 Days and 20.9 Hours
Core Tip
Core Tip: Aging is becoming more severe in China. The present study showed that decreased skeletal muscle mass is associated with the presence of diabetes mellitus in males but not in females; non-alcoholic fatty liver disease weakens this association. The results suggested that stratified management of diabetes mellitus should be considered according to skeletal muscle mass and non-alcoholic fatty liver disease.