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World J Diabetes. Oct 15, 2021; 12(10): 1704-1718
Published online Oct 15, 2021. doi: 10.4239/wjd.v12.i10.1704
Tale of two kinases: Protein kinase A and Ca2+/calmodulin-dependent protein kinase II in pre-diabetic cardiomyopathy
Pamela Gaitán-González, Rommel Sánchez-Hernández, José-Antonio Arias-Montaño, Angélica Rueda
Pamela Gaitán-González, Angélica Rueda, Department of Biochemistry, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico
Rommel Sánchez-Hernández, José-Antonio Arias-Montaño, Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico
Author contributions: Gaitán-González P and Sánchez-Hernández R collected the data, prepared tables, and drafted the manuscript; Arias-Montaño JA and Rueda A designed the review and wrote the manuscript.
Supported by SEP-Cinvestav Project, No. FIDSC 2018/2; and SEP-Conacyt Ciencia Básica 2017-2018, No. A1-S-9082 (to Rueda A).
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Angélica Rueda, PhD, Professor, Department of Biochemistry, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, San Pedro Zacatenco, Ciudad de México 07360, Mexico. arueda@cinvestav.mx
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: June 23, 2021
Revised: July 28, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: October 15, 2021
Processing time: 230 Days and 5.6 Hours
Core Tip

Core Tip: Metabolic syndrome affects heart function leading to pre-diabetic cardiomyopathy. In an attempt to overcome contractility dysfunction, the activity of the sympathetic nervous system increases, but chronic stimulation of β-adrenoceptors leads to alterations in both protein kinase A and Ca2+/calmodulin-dependent protein kinase II activity, the main effectors of the β-adrenergic response. This work recapitulates current evidence about the participation of protein kinase A and Ca2+/calmodulin-dependent protein kinase II in experimental pre-diabetic cardiomyopathy, emphasizing the prevailing role of CaMKII in the development of cardiomyocyte Ca2+ mishandling and myocardial dysfunction associated with pre-diabetes.