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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2021; 12(10): 1655-1673
Published online Oct 15, 2021. doi: 10.4239/wjd.v12.i10.1655
Role of nucleic acid sensing in the pathogenesis of type 1 diabetes
Darshan Badal, Naresh Sachdeva, Deep Maheshwari, Preetam Basak
Darshan Badal, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Naresh Sachdeva, Deep Maheshwari, Preetam Basak, Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Author contributions: Badal D and Maheshwari D performed the literature search and wrote the manuscript; Basak P performed the literature search, compiled the figure, and assisted in editing the manuscript; Sachdeva N drafted the structure of the manuscript and edited the whole manuscript; Sachdeva N and Badal D contributed equally to the manuscript and are joint first authors.
Supported by Council of Scientific and Industrial Research, Government of India, No. 27 (0328)/17/EMR-II (awarded to Sachdeva N).
Conflict-of-interest statement: The authors declare that there are no conflicts of interest associated with this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Naresh Sachdeva, MSc, PhD, Additional Professor, Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. naresh_pgi@hotmail.com
Received: January 28, 2021
Peer-review started: January 28, 2021
First decision: May 3, 2021
Revised: May 22, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: October 15, 2021
Processing time: 257 Days and 22 Hours
Core Tip

Core Tip: Under abnormal physiological conditions, such as excessive cellular stress or apoptosis, endogenous self-nucleic acids like DNA, RNA or mitochondrial DNA accumulate in extranuclear compartments or extracellular spaces or form complexes with host proteins. Such situations sometimes lead to the failure of discriminating mechanisms of nucleic acid sensors leading to proinflammatory responses as seen in autoimmune diseases like systemic lupus erythematosus, psoriasis and to some extent in type 1 diabetes (T1D). The understanding of the role of nucleic acid-sensing and their downstream signaling pathways is gradually evolving and provides another avenue in exploring therapeutic options for treating autoimmune diseases like T1D.