Case Control Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2021; 12(1): 47-55
Published online Jan 15, 2021. doi: 10.4239/wjd.v12.i1.47
Relationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes
Ning-Ning Hou, Cheng-Xia Kan, Na Huang, Yong-Ping Liu, En-Wen Mao, Yu-Ting Ma, Fang Han, Hong-Xi Sun, Xiao-Dong Sun
Ning-Ning Hou, Cheng-Xia Kan, Na Huang, Yong-Ping Liu, En-Wen Mao, Yu-Ting Ma, Hong-Xi Sun, Xiao-Dong Sun, Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Fang Han, Department of Pathology, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Author contributions: Huang N and Kan CX performed the majority of experiments and wrote the manuscript; Hou NN and Sun XD designed the study and revised the manuscript; Liu YP, Mao EW, Ma YT, Sun HX, and Han F provided analytical tools.
Supported by National Natural Science Foundation of China, No. 81870593; Natural Science Foundation of Shandong Province of China, No. ZR2018MH008; Shandong Province Higher Educational Science and Technology Program for Youth Innovation, No. 2020KJL004; Municipal Science and Technology Development Program of Weifang, No. 2018YX025.
Institutional review board statement: The study was approved by the Medical Ethics Committee of the Affiliated Hospital of Weifang Medical University.
Informed consent statement: Informed consent was obtained from all individuals.
Conflict-of-interest statement: No conflict of interest is reported.
Data sharing statement: The datasets analyzed during the present study are available from the corresponding authors on reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Dong Sun, MD, PhD, Associate Professor, Doctor, Research Fellow, Department of Endocrinology, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Weifang 261031, Shandong Province, China. xiaodong.sun@wfmc.edu.cn
Received: July 16, 2020
Peer-review started: July 16, 2020
First decision: September 17, 2020
Revised: September 28, 2020
Accepted: November 10, 2020
Article in press: November 10, 2020
Published online: January 15, 2021
Processing time: 175 Days and 5.3 Hours
Core Tip

Core Tip: This study explored the relationship between circulating Dickkopf-1 levels and albuminuria in type 2 diabetic individuals. Multiple characteristics and metabolic indices were collected, and analyses were performed using various statistical methods. The main finding was that circulating Dickkopf-1 levels were negatively correlated with albuminuria and lower Dickkopf-1 could be a risk factor for albuminuria in diabetes.