Prospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2020; 11(5): 202-212
Published online May 15, 2020. doi: 10.4239/wjd.v11.i5.202
Severity of the metabolic syndrome as a predictor of prediabetes and type 2 diabetes in first degree relatives of type 2 diabetic patients: A 15-year prospective cohort study
Rokhsareh Meamar, Masoud Amini, Ashraf Aminorroaya, Maryam Nasri, Majid Abyar, Awat Feizi
Rokhsareh Meamar, Isfahan Endocrine and Metabolism Research Center, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Masoud Amini, Ashraf Aminorroaya, Majid Abyar, Awat Feizi, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Maryam Nasri, Grovemead Health Center, London NW4-3EB, United Kingdom
Awat Feizi, Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Author contributions: Amini M generated the idea and designed the Isfahan diabetes prevention study, participated in most of the experiments, revising the paper critically for important intellectual content; Meamar R generated the idea and designed the current secondary study, wrote all major parts of the article and checked it for intellectual content and revised it; Feizi A supervised the current secondary study and drafted the paper and revised it critically for important intellectual content and performed all statistical analyses; Aminorroaya A essentially participated as co-investigator in Isfahan diabetes prevention study, revised paper critically for important intellectual content; Nasri M edited and resolved grammatical errors in the article; Abyar M assisted in data collection and preparation and statistical analysis.
Supported by Isfahan Endocrine and Metabolism Research Center, No. 95017.
Institutional review board statement: The study was reviewed and approved by the institutional review boards of Isfahan University of Medical Sciences, Isfahan, Iran. Study project number: 95017.
Informed consent statement: All study participants, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this manuscript having no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Awat Feizi, PhD, Professor, Statistician, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, P.O. Box 319, Hezar-Jerib Ave, Isfahan 81746-73461, Iran. awat_feiz@hlth.mui.ac.ir
Received: December 16, 2019
Peer-review started: December 16, 2019
First decision: January 6, 2020
Revised: March 16, 2020
Accepted: March 23, 2020
Article in press: March 23, 2020
Published online: May 15, 2020
Core Tip

Core tip: This prospective cohort study showed that metabolic syndrome severity score at baseline, in first degree relative of type 2 diabetes mellitus patients with normal glucose tolerance, predicts the incidence of future diabetes and prediabetes. In this study, the cut off values of metabolic syndrome Z-score for predicting prediabetes and diabetes were 0.94 and 0.97, respectively. This negligible difference between two groups in terms of cut off values highlights the importance of intervention at prediabetes stage.