Caputo V, Termine A, Strafella C, Giardina E, Cascella R. Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes. World J Diabetes 2020; 11(5): 155-164 [PMID: 32477452 DOI: 10.4239/wjd.v11.i5.155]
Corresponding Author of This Article
Emiliano Giardina, PhD, Associate Professor, Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Via Ardeatina 354, Rome 00142, Italy. emiliano.giardina@uniroma2.it
Research Domain of This Article
Genetics & Heredity
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. May 15, 2020; 11(5): 155-164 Published online May 15, 2020. doi: 10.4239/wjd.v11.i5.155
Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes
Valerio Caputo, Andrea Termine, Claudia Strafella, Emiliano Giardina, Raffaella Cascella
Valerio Caputo, Claudia Strafella, Emiliano Giardina, Raffaella Cascella, Department of Biomedicine and Prevention, Tor Vergata University, Rome 00133, Italy
Valerio Caputo, Andrea Termine, Claudia Strafella, Emiliano Giardina, Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome 00142, Italy
Andrea Termine, Experimental and Behavioral Neurophysiology Laboratory, Santa Lucia Foundation, Rome 00142, Italy
Raffaella Cascella, Department of Biomedical Sciences, Catholic University Our Lady of Good Counsel, Tirana 1000, Albania
Author contributions: Caputo V and Termine A conceived of the study, performed the literature search, and wrote the manuscript; Strafella C, Giardina E and Cascella R conceived of the study and revised the manuscript; all authors approved the final version of the article.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Emiliano Giardina, PhD, Associate Professor, Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Via Ardeatina 354, Rome 00142, Italy. emiliano.giardina@uniroma2.it
Received: December 27, 2019 Peer-review started: December 11, 2019 First decision: January 13, 2020 Revised: February 10, 2020 Accepted: March 22, 2020 Article in press: March 22, 2020 Published online: May 15, 2020 Processing time: 135 Days and 19.9 Hours
Core Tip
Core tip: Populations’ progressive aging raises important challenges to be faced, including the increased prevalence of metabolic, neurodegenerative and movement disorders, especially of type 2 diabetes, Alzheimer’s disease and Parkinson’s disease. These disorders are characterized by a multifactorial etiology, involving genetic and non-genetic factors, which may overlap. This review will discuss the shared (epi)genomic features, the role of mutually-associated genetic variants, common gene expression profiles and epigenetic background leading to development and progression of such disorders. Overall, this review highlights the importance of characterizing the “disease interactome” in order to establish adequate personalized and preventative healthcare approaches for the ageing populations.
