Clinical Trials Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2020; 11(11): 501-513
Published online Nov 15, 2020. doi: 10.4239/wjd.v11.i11.501
Altered regional homogeneity in patients with diabetic vitreous hemorrhage
Yu-Qing Zhang, Fei-Yin Zhu, Li-Ying Tang, Biao Li, Pei-Wen Zhu, Wen-Qing Shi, Qi Lin, You-Lan Min, Yi Shao, Qiong Zhou
Yu-Qing Zhang, Fei-Yin Zhu, Li-Ying Tang, Biao Li, Pei-Wen Zhu, Wen-Qing Shi, Qi Lin, You-Lan Min, Yi Shao, Qiong Zhou, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Yu-Qing Zhang, Fei-Yin Zhu, Li-Ying Tang, Biao Li, Pei-Wen Zhu, Wen-Qing Shi, Qi Lin, You-Lan Min, Yi Shao, Qiong Zhou, Department of Ophthalmology, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi Province, China
Li-Ying Tang, Department of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen 361101, Fujian Province, China
Li-Ying Tang, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, Fujian Province, China
Li-Ying Tang, Department of Ophthalmology, Eye Institute of Xiamen University, Xiamen 361102, Fujian Province, China
Author contributions: Zhang YQ was involved in the data curation and writing of the original draft; Zhu FT performed the data curation and formal analysis, and participated in the writing and editing of the manuscript; Tang LY was involved in the data curation, and writing, review, and editing of the manuscript; Li B took part in the data curation and supervision of the study; Zhu PW was involved in the study conceptualization and methodology design; Shi WQ was involved in data validation and visualization; Lin Q participated in the methodology design and data visualization; Min LY was involved in methodology design and data validation; Shao Y and Zhou Q was involved in the study conceptualization, data curation, funding acquisition, and project administration; all authors have read and approved the final manuscript.
Institutional review board statement: The study methods and protocols were approved by the Medical Ethics Committee of the First Affiliated Hospital of Nanchang University (Ethical approval number: 2014022), and followed the principles of the Declaration of Helsinki. All subjects were notified of the objectives and content of the study and latent risks, and then provided written informed consent to participate.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: This is not an industry supported study. The authors report no conflicts of interest in this work.
Data sharing statement: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
CONSORT 2010 statement: The manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiong Zhou, MD, Director, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai Main Street, Nanchang 330006, Jiangxi Province, China. qiongz-ms@126.com
Received: February 21, 2020
Peer-review started: February 21, 2020
First decision: April 22, 2020
Revised: June 11, 2020
Accepted: September 27, 2020
Article in press: September 27, 2020
Published online: November 15, 2020
Processing time: 260 Days and 15.2 Hours
Core Tip

Core Tip: We found that patients with diabetic vitreous hemorrhage (DVH) had abnormal spontaneous activity in many brain regions. The abnormalities of brain neural homogeneity may be associated with the altered best-corrected visual acuity of the contralateral eye and depression which occurred in DVH patients. These findings may provide important information for the understanding of neural changes in DVH patients and lay a foundation for further study.