Haghighatdoost F, Amini M, Aminorroaya A, Abyar M, Feizi A. Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study. World J Diabetes 2019; 10(6): 350-361 [PMID: 31231458 DOI: 10.4239/wjd.v10.i6.350]
Corresponding Author of This Article
Awat Feizi, PhD, Professor, Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, P.O. Box 319, Hezar-Jerib Ave, Isfahan 81746-73461, Iran. awat_feiz@hlth.mui.ac.ir
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fahimeh Haghighatdoost, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Fahimeh Haghighatdoost, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Masoud Amini, Ashraf Aminorroaya, Majid Abyar, Awat Feizi, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Awat Feizi, Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Author contributions: Amini M and Aminorroaya A contributed to the concept, design, and data collection; Feizi A and Majid Abyar M analyzed data and interpreted results; Haghighatdoost F interpreted results and drafted the manuscript; Feizi A supervised the current study; All authors approved the final version of manuscript.
Institutional review board statement: This study was conducted at Isfahan Endocrine and Metabolism Research Center and approved by the ethics committee of Isfahan University of Medical Sciences.
Informed consent statement: All involved subjects gave their informed written consent prior to study inclusion.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Awat Feizi, PhD, Professor, Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, P.O. Box 319, Hezar-Jerib Ave, Isfahan 81746-73461, Iran. awat_feiz@hlth.mui.ac.ir
Telephone: +98-313-7923250 Fax: +98-313-7923232
Received: February 24, 2019 Peer-review started: February 26, 2019 First decision: March 11, 2019 Revised: May 10, 2019 Accepted: May 14, 2019 Article in press: May 14, 2019 Published online: June 15, 2019 Processing time: 111 Days and 2 Hours
Core Tip
Core tip: The risk of developing prediabetes based on metabolic/obesity phenotypes has been poorly investigated. In a 14-year follow-up cohort study, we observed that metabolically unhealthy normal weight, metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) were at higher risk for developing prediabetes compared to metabolically healthy normal weight (MHNW) subjects. The results stratified by sex demonstrated no significant association in men, while the risk of prediabetes development was significantly higher in all metabolic/obesity phenotypes in women compared to MHNW. Transforming from each phenotype to MHNW or MHO was not related to an increased risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes.
