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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2019; 10(4): 260-268
Published online Apr 15, 2019. doi: 10.4239/wjd.v10.i4.260
Published online Apr 15, 2019. doi: 10.4239/wjd.v10.i4.260
Are serum leptin levels predicted by lipoproteins, vitamin D and body composition?
Aysha Habib Khan, Departments of Pathology and Laboratory Medicine and Medicine, Aga Khan University, Karachi 74800, Pakistan
Syeda Sadia Fatima, Department of Basic Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan
Ahmed Raheem, Lena Jafri, Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi 74800, Pakistan
Author contributions: Khan AH analyzed the data and contributed in discussion writing manuscript and made critical revisions related to the important intellectual content of the manuscript; Jafri L and Fatima SS conceived the idea, decided the design of the study, collected data, performed analysis and interpretation of the data, and participated in writing of the manuscript; Raheem A contributed statistical analysis and results writing; All authors gave final approval of the version of the article to be published.
Conflict-of-interest statement: There are no conflicts of interest arising from this work.
PRISMA 2009 Checklist statement: PRISMA 2009 Checklist statement has been submitted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lena Jafri, FCPS, MBBS, Assistant Professor, Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan. lena.jafri@aku.edu
Telephone: +92-21-34861946 Fax: +92-21-24932095
Received: February 8, 2019
Peer-review started: February 10, 2019
First decision: March 11, 2015
Revised: April 11, 2015
Accepted: April 14, 2019
Article in press: April 14, 2019
Published online: April 15, 2019
Processing time: 66 Days and 22.5 Hours
Peer-review started: February 10, 2019
First decision: March 11, 2015
Revised: April 11, 2015
Accepted: April 14, 2019
Article in press: April 14, 2019
Published online: April 15, 2019
Processing time: 66 Days and 22.5 Hours
Core Tip
Core tip: The paper explored variables like anthropometric measurements, body composition, vitamin D and lipoproteins as predictors for serum leptin levels among representative population of healthy adults in Pakistan. The cross-sectional nature of this study could not elucidate causal relationships. However, it outlines important interplay between circulating leptin, vitamin D and body composition. The results indicate that basal metabolic rate, muscle mass, body fat percent, bone mass and serum vitamin D have an impact on serum leptin.