Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2019; 10(2): 133-136
Published online Feb 15, 2019. doi: 10.4239/wjd.v10.i2.133
Published online Feb 15, 2019. doi: 10.4239/wjd.v10.i2.133
Bilateral gangrene of fingers in a patient on empagliflozin: First case report
Rajasree Pai Ramachandra Pai, Endocrinology and Metabolism and Internal Medicine, San Francisco VA Medical Center, Santa Rosa, CA 95492, United States
Raghesh Varot Kangath, Infectious Diseases and Internal Medicine, San Francisco VA Medical Center, Santa Rosa, CA 95492, United States
Author contributions: Ramachandra Pai RP prepared, reviewed and edited the manuscript; Kangath RV assisted in reviewing and editing the manuscript.
Informed consent statement: Written consent from the patient was obtained.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rajasree Pai Ramachandra Pai, MD, Staff Physician, Endocrinology and Metabolism and Internal Medicine, San Francisco VA Medical Center, 4150 Clement Street, Santa Rosa, CA 95492, United States. drrajashree.pai@gmail.com
Telephone: +1-415-2214810
Received: January 3, 2019
Peer-review started: January 4, 2019
First decision: January 12, 2019
Revised: February 13, 2019
Accepted: February 13, 2019
Article in press: February 14, 2019
Published online: February 15, 2019
Processing time: 46 Days and 8.6 Hours
Peer-review started: January 4, 2019
First decision: January 12, 2019
Revised: February 13, 2019
Accepted: February 13, 2019
Article in press: February 14, 2019
Published online: February 15, 2019
Processing time: 46 Days and 8.6 Hours
Core Tip
Core tip: Empagliflozin can cause finger gangrene in patients with type 2 diabetes mellitus. Empaglifozin has gained popularity recently as a newer anti diabetic agent with improved cardiovascular outcomes and better glycemic control in addition to lowering blood pressure and helping with weight loss. Lack of proper awareness about this condition can lead to progression of disease if not identified early on and can result in amputations. This medication should be used with caution in patients who have high risk of gangrene such as that on prednisone and in those with diabetic neuropathy.