Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2018; 9(7): 132-137
Published online Jul 15, 2018. doi: 10.4239/wjd.v9.i7.132
New-onset diabetes after kidney transplantation: Incidence and associated factors
Vânia Gomes, Florbela Ferreira, José Guerra, Maria João Bugalho
Vânia Gomes, Florbela Ferreira, Maria João Bugalho, Endocrinology, Diabetes and Metabolism Department, Santa Maria Hospital, Lisbon 1649-035, Portugal
José Guerra, Nephrology and Kidney Transplantation Department, Santa Maria Hospital, Lisbon 1649-035, Portugal
Author contributions: Gomes V wrote the manuscript, collected the data and performed the data analysis; Guerra J collected the data; Guerra J, Ferreira F and Bugalho MJ reviewed the manuscript for important intellectual content; all authors participated in designing the study.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Santa Maria Hospital (No. 406/17).
Informed consent statement: Informed consent was not required for study participation or data publication because the clinical data were collected from an institutional database and had been anonymized before analysis.
Conflict-of-interest statement: All authors declare no conflicts-of-interest in relation to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Vânia Gomes, MD, Doctor, Endocrinology, Diabetes and Metabolism Department, Santa Maria Hospital, Avenida Professor Egas Moniz, Lisbon 1649-035, Portugal. vania.rodrigues.gomes@gmail.com
Telephone: +351-912-993251
Received: March 22, 2018
Peer-review started: March 23, 2018
First decision: May 8, 2018
Revised: May 24, 2018
Accepted: June 13, 2018
Article in press: June 13, 2018
Published online: July 15, 2018
Processing time: 114 Days and 14 Hours
ARTICLE HIGHLIGHTS
Research background

New-onset diabetes after transplantation (NODAT) is a common complication of kidney transplantation, correlated with poorer outcomes. Its incidence varies greatly between studies, and multiple risk factors have been associated with its onset.

Research motivation

Albeit a frequent complication of kidney transplant, very few studies of NODAT in the Portuguese population have been published.

Research objectives

To evaluate the incidence and associated factors of NODAT among kidney transplant recipients in a Portuguese hospital.

Research methods

Retrospective study of consecutive adult nondiabetic patients, who underwent kidney transplant between January 2012 and March 2016 in a central Portuguese hospital.

Research results

NODAT was identified in 27.2% of the kidney transplant recipients. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation. Higher pretransplant fasting plasma glucose levels and occurrence of pretransplant impaired fasting glucose (IFG) were predictive risk factors for NODAT development.

Research conclusions

Periodical blood glucose screening in patients waiting for a kidney transplant is important to identify those at risk for and to minimize progression to NODAT and its potentially severe complications.

Research perspectives

Clinicians should be aware of NODAT risk factors, namely pretransplant IFG, to perform a tighter surveillance of patients in these conditions. Multicentric studies are required to investigate other risk factors possibly implicated in NODAT development.