Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2024; 15(3): 403-417
Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.403
Associations between Geriatric Nutrition Risk Index, bone mineral density and body composition in type 2 diabetes patients
Xiao-Xiao Zhu, Kai-Feng Yao, Hai-Yan Huang, Li-Hua Wang
Xiao-Xiao Zhu, Department of Pediatrics, The Second Affiliated Hospital of Nantong University, First People’s Hospital of Nantong City, Nantong 226001, Jiangsu Province, China
Kai-Feng Yao, Li-Hua Wang, Department of Nursing, The Second Affiliated Hospital of Nantong University, First People’s Hospital of Nantong City, Nantong 226001, Jiangsu Province, China
Hai-Yan Huang, Department of Endocrinology, The Second Affiliated Hospital of Nantong University, First People’s Hospital of Nantong City, Nantong 226001, Jiangsu Province, China
Author contributions: Zhu XX and Wang LH designed the research; Zhu XX and Yao KF collected the data; Zhu XX and Huang HY analyzed the data; Zhu XX and Yao KF wrote the paper; Wang LH reviewed the paper.
Supported by Social Development Projects of Nantong, No. MS22021008 and No. QNZ2022005.
Institutional review board statement: The study was approved by the institutional review board of The Second Affiliated Hospital of Nantong University, First People’s Hospital of Nantong City (approval number: 2021KT063).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Hua Wang, MNurs, Chief Nurse, Department of Nursing, The Second Affiliated Hospital of Nantong University, First People’s Hospital of Nantong City, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. wlh512512@163.com
Received: August 24, 2023
Peer-review started: August 24, 2023
First decision: November 21, 2023
Revised: December 8, 2023
Accepted: January 24, 2024
Article in press: January 24, 2024
Published online: March 15, 2024
ARTICLE HIGHLIGHTS
Research background

In people with type 2 diabetes mellitus (T2DM), the association between nutrition, sarcopenia, and osteoporosis has rarely been explored.

Research motivation

The relationship between nutritional status and bone mass has been observed in different populations, including individuals with chronic obstructive pulmonary disease, rheumatoid arthritis, and end-stage renal disease.

Research objectives

Assess the associations among nutrition, bone mineral density (BMD) and body composition in patients with T2DM.

Research methods

A total of 689 patients with T2DM were included to perform a retrospective analysis. The general information and biochemical indices of these patients were statistically analyzed.

Research results

Those who had a high Geriatric Nutritional Risk Index (GNRI) tended to be younger and had lower HbA1c, higher BMD at all bone sites, and higher appendicular skeletal muscle index.

Research conclusions

Poor nutrition, as indicated by a low GNRI, was associated with low levels of ASMI and BMD at all bone sites in type 2 diabetes mellitus patients.

Research perspectives

We used a retrospective study to explore the association between nutrition, sarcopenia, and osteoporosis in patients with T2DM.