Published online Mar 25, 2016. doi: 10.4239/wjd.v7.i6.112
Peer-review started: November 3, 2015
First decision: November 30, 2015
Revised: December 13, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: March 25, 2016
Processing time: 147 Days and 0.3 Hours
For the last decade, low serum amylase (hypoamylasemia) has been reported in certain common cardiometabolic conditions such as obesity, diabetes (regardless of type), and metabolic syndrome, all of which appear to have a common etiology of insufficient insulin action due to insulin resistance and/or diminished insulin secretion. Some clinical studies have shown that salivary amylase may be preferentially decreased in obese individuals, whereas others have revealed that pancreatic amylase may be preferentially decreased in diabetic subjects with insulin dependence. Despite this accumulated evidence, the clinical relevance of serum, salivary, and pancreatic amylase and the underlying mechanisms have not been fully elucidated. In recent years, copy number variations (CNVs) in the salivary amylase gene (AMY1), which range more broadly than the pancreatic amylase gene (AMY2A and AMY2B), have been shown to be well correlated with salivary and serum amylase levels. In addition, low CNV of AMY1, indicating low salivary amylase, was associated with insulin resistance, obesity, low taste perception/satiety, and postprandial hyperglycemia through impaired insulin secretion at early cephalic phase. In most populations, insulin-dependent diabetes is less prevalent (minor contribution) compared with insulin-independent diabetes, and obesity is highly prevalent compared with low body weight. Therefore, obesity as a condition that elicits cardiometabolic diseases relating to insulin resistance (major contribution) may be a common determinant for low serum amylase in a general population. In this review, the novel interpretation of low serum, salivary, and pancreas amylase is discussed in terms of major contributions of obesity, diabetes, and metabolic syndrome.
Core tip: Low serum amylase was believed to occur in uncommon conditions such as type 1 diabetes, advanced chronic pancreatitis, and cystic fibrosis. However, in the last decade, low serum amylase has been observed in more common conditions related with insulin resistance than was previously believed. In this review, a novel interpretation for low serum, salivary, and pancreatic amylase is discussed, particularly in terms of the cardiometabolic conditions of obesity, diabetes, and metabolic syndrome.