Copyright
©2012 Baishideng. All rights reserved.
World J Diabetes. Aug 15, 2012; 3(8): 156-157
Published online Aug 15, 2012. doi: 10.4239/wjd.v3.i8.156
Published online Aug 15, 2012. doi: 10.4239/wjd.v3.i8.156
Hyperinsulinemia and insulin resistance in a patient with type 2 diabetes complicated with myelofibrosis
Hidetaka Hamasaki, Shuichi Mishima, Hidekatsu Yanai, Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba 272-8516, Japan
Author contributions: Hamasaki H, Mishima S and Yanai H contributed to the conception, writing and editing of the letter; and all authors also treated the patient presented in the letter, and contributed data collection.
Supported by The Grant of National Center for Global Health and Medicine, No. 22-120
Correspondence to: Hidekatsu Yanai, MD, PhD, FACP, Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba 272-8516, Japan. dyanai@hospk.ncgm.go.jp
Telephone: +81-47-3733501 Fax: +81-47-3721858
Received: May 22, 2012
Revised: July 18, 2012
Accepted: August 8, 2012
Published online: August 15, 2012
Revised: July 18, 2012
Accepted: August 8, 2012
Published online: August 15, 2012
Abstract
Inflammation induces insulin resistance and hyperinsulinemia due to elevation of serum cytokines such as tumor necrosis factor-α and interleukins. Chronic myeloproliferative diseases including myelofibrosis show higher serum interleukin levels than healthy subjects, which has been suggested to be the useful markers for disease activity. However, an association between myelofibrosis and insulin resistance has not ever been discussed anywhere. Here we report a case of type 2 diabetes showing remarkable hyperinsulinemia and insulin resistance possibly due to myelofibrosis.