Luis-Rodríguez D, Martínez-Castelao A, Górriz JL, Álvaro F, Navarro-González JF. Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy. World J Diabetes 2012; 3(1): 7-18 [PMID: 22253941 DOI: 10.4239/wjd.v3.i1.7]
Corresponding Author of This Article
Juan F Navarro-González, MD, PhD, FASN, Nephrology Service, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
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World J Diabetes. Jan 15, 2012; 3(1): 7-18 Published online Jan 15, 2012. doi: 10.4239/wjd.v3.i1.7
Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy
Desirée Luis-Rodríguez, Alberto Martínez-Castelao, José Luis Górriz, Fernando de Álvaro, Juan F Navarro-González
Desirée Luis-Rodríguez, Alberto Martínez-Castelao, José Luis Górriz, Fernando de Álvaro, Juan F Navarro-González, Grupo Español para el Estudio de la Nefropatía Diabética (GEENDIAB), Spain
Desirée Luis-Rodríguez, Juan F Navarro-González, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Alberto Martínez-Castelao, Nephrology Service, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
José Luis Górriz, Nephrology Service, University Hospital Dr. Peset, 46017 Valencia, Spain
Fernando de Álvaro, Nephrology Service, University Hospital Infanta Sofía, 28702 Madrid, Sapin
Author contributions: Luis-Rodríguez D reviewed the literature and wrote the first draft of the manuscript; Martínez-Castelao A, Górriz JL and De Álvaro F contributed equally to the literature search and reviewed the draft and revised versions of the manuscript; Navarro González JF conceived the original idea, reviewed the first draft and revised versions, and finalized the manuscript. All authors approved the final version of the manuscript to be published.
Supported by Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III-Fondo de Investigación Sanitaria: PI07/0870 and PI10/576), Ministerio de Sanidad y Política Social (Dirección General de Terapias Avanzadas y Trasplante: TRA-182), Sociedad Española de Nefrología y ACINEF
Correspondence to: Juan F Navarro-González, MD, PhD, FASN, Nephrology Service, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
Telephone: +34-96-922602061 Fax: +34-96-922602349
Received: August 26, 2011 Revised: December 9, 2011 Accepted: January 9, 2012 Published online: January 15, 2012
Abstract
Diabetes mellitus and its complications are becoming one of the most important health problems in the world. Diabetic nephropathy is now the main cause of end-stage renal disease. The mechanisms leading to the development and progression of renal injury are not well known. Therefore, it is very important to find new pathogenic pathways to provide opportunities for early diagnosis and targets for novel treatments. At the present time, we know that activation of innate immunity with development of a chronic low grade inflammatory response is a recognized factor in the pathogenesis of diabetic nephropathy. Numerous experimental and clinical studies have shown the participation of different inflammatory molecules and pathways in the pathophysiology of this complication.
