Nagoba BS, Gavkare AM, Nanaware N, Mumbre SS, Bhavthankar S. Systemic immune indicators: Early predictors of renal damage in children with newly diagnosed type 1 diabetes mellitus. World J Diabetes 2025; 16(7): 108209 [DOI: 10.4239/wjd.v16.i7.108209]
Corresponding Author of This Article
Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research, Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com
Research Domain of This Article
Immunology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jul 15, 2025; 16(7): 108209 Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.108209
Systemic immune indicators: Early predictors of renal damage in children with newly diagnosed type 1 diabetes mellitus
Basavraj S Nagoba, Ajay M Gavkare, Neeta Nanaware, Sachin S Mumbre, Sachin Bhavthankar
Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research, Latur 413531, Maharashtra, India
Ajay M Gavkare, Department of Physiology, Maharashtra Institute of Medical Sciences and Research, Latur 413531, Maharashtra, India
Neeta Nanaware, Department of Physiology, Vilasrao Deshmukh Government Medical College, Latur 413512, Maharashtra, India
Sachin S Mumbre, Department of Community Medicine, Ashwini Rural Medical College, Solapur 413006, India
Sachin Bhavthankar, Department of Biochemistry, Maharashtra Institute of Medical Sciences and Research, Latur 413512, India
Co-first authors: Basavraj S Nagoba and Ajay M Gavkare.
Author contributions: Nagoba BS and Gavkare AM contributed to the manuscript writing and editing, and review of literature as co-first authors. Nagoba BS designed the overall concept and outline of the manuscript; Gavkare AM, Nanaware N, Mumbare SS, and Bhavthankar SS contributed to the discussion and design of the manuscript. All authors contributed to finalizing the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research, Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com
Received: April 7, 2025 Revised: April 24, 2025 Accepted: May 16, 2025 Published online: July 15, 2025 Processing time: 98 Days and 23.4 Hours
Abstract
This editorial delves into the potential of systemic immune indicators (SIIs) as early predictors of renal damage in children with newly diagnosed type 1 diabetes mellitus. By exploring the recent study published by Cao et al, this article aims to highlight the importance of early detection and intervention. This study comprehensively analyzes various SIIs, examining their correlation with renal complications in newly diagnosed type 1 diabetic children. The findings reveal a significant association between immune system dysregulation and the onset of renal damage, suggesting that certain immune indicators can be early markers for predicting renal complications. This editorial emphasizes the clinical implications and applications of utilizing SIIs for early detection in pediatric diabetes care. It underscores the importance of innovative diagnostic approaches and illustrates real-world applications and outcomes. Additionally, it addresses the challenges and considerations in adopting these indicators and outlines future research directions to enhance diabetes management in children.
Core Tip: Taking into consideration the growing concern of diabetic nephropathy in children with type 1 diabetes mellitus and examining the promise of systemic immune indicators as predictive tools, healthcare providers have the opportunity to reshape the narrative of diabetes management, offering hope for a healthier future for pediatric patients. It is also imperative that healthcare providers and researchers continue to explore the role of systemic immune indicators in diabetes management to further enhance the understanding and treatment of this chronic condition.
