Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.107187
Revised: May 6, 2025
Accepted: June 5, 2025
Published online: July 15, 2025
Processing time: 111 Days and 0.5 Hours
Underdiagnosis of peripheral arterial disease results in inadequate treatment and more serious consequences. Hence, clinicians have focused on early diagnosis and treatment.
To investigate the effectiveness of the combination of doppler ultrasonography (DUS), three-dimensional dynamic contrast-enhanced magnetic resonance an
This study retrospectively analyzed the imaging and clinical data of 116 patients diagnosed with DM complicated with lower extremity vascular diseases from January 2021 to June 2023. All patients underwent unilateral or bilateral DUS, CTA, and CE-MRA as well as invasive digital subtraction angiography (DSA). The application values of DUS, CE-MRA, and CTA were compared.
A total of 152 lower extremity arteries in the 116 patients were graded following the classification of vascular branches. The Kappa values between DUS and DSA were 0.780, 0.755, and 0.806 for diagnosing moderate stenosis and 0.484, 0.699, and 0.449 for severe stenosis of grade 1 arteries, grade 2 arteries, and grade 3 arteries, respectively. The Kappa values between CE-MRA and DSA were 0.784, 0.814, and 0.835 for diagnosing moderate stenosis and 0.694, 0.748, and 0.606 for severe stenosis of grade 1 arteries, grade 2 arteries, and grade 3 arteries, respectively. The Kappa values between CTA and DSA were 0.900, 0.858, and 0.878 for diagnosing moderate stenosis and 0.882, 0.823, and 0.756 for severe stenosis of grade 1 arteries, grade 2 arteries, and grade 3 arteries, respectively.
DUS, CE-MRA, and CTA demonstrated comparable accuracy in diagnosing lower extremity arterial disease in DM, and the consistency between CTA and DSA diagnoses was higher than the other two imaging methods.
Core Tip: Diabetes mellitus is a major risk factor for lower extremity peripheral arterial disease, and lower extremity complications are prevalent and increasing globally. However, peripheral arterial disease underdiagnosis results in undertreatment and subsequent complications with more serious consequences. Therefore, in this study we analyzed the diagnostic value of color doppler ultrasonography, magnetic resonance multimodal imaging, and CT angiography in diabetes mellitus complicated with lower limb arterial disease using digital subtraction angiography as the gold standard for diagnosing this disease.