Akpoveta ED, Okpete UE, Byeon H. Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes. World J Diabetes 2025; 16(5): 104841 [DOI: 10.4239/wjd.v16.i5.104841]
Corresponding Author of This Article
Haewon Byeon, PhD, Academic Editor, Associate Professor, Department of Future Technology, Korea University of Technology and Education, 1600 Chungjeol-ro, Byeongcheon-myeon, Dongnam-gu, Cheonan-si, Chungcheongnam-do, Cheonan 31253, South Korea. bhwpuma@naver.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. May 15, 2025; 16(5): 104841 Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.104841
Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes
Eguono Deborah Akpoveta, Uchenna E Okpete, Haewon Byeon
Eguono Deborah Akpoveta, Department of Community Medicine, Federal Medical Centre, Asaba 322022, Delta state, Nigeria
Uchenna E Okpete, Department of Digital Anti-aging Healthcare (BK21), Inje University, Gimhae 50834, South Korea
Haewon Byeon, Department of Future Technology, Korea University of Technology and Education, Cheonan 31253, South Korea
Co-first authors: Eguono Deborah Akpoveta and Uchenna E Okpete.
Author contributions: Akpoveta ED, Okpete UE, and Byeon H contributed to this paper and assisted with writing the article; Byeon H designed the study; Akpoveta ED and Okpete UE were involved in data interpretation, developed methodology, and contributed equally as co-first authors.
Supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, No. NRF-RS-2023-00237287.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Haewon Byeon, PhD, Academic Editor, Associate Professor, Department of Future Technology, Korea University of Technology and Education, 1600 Chungjeol-ro, Byeongcheon-myeon, Dongnam-gu, Cheonan-si, Chungcheongnam-do, Cheonan 31253, South Korea. bhwpuma@naver.com
Received: January 6, 2025 Revised: February 23, 2025 Accepted: March 11, 2025 Published online: May 15, 2025 Processing time: 112 Days and 2.7 Hours
Abstract
Managing type 2 diabetes mellitus remains a significant challenge, particularly for individuals with persistently poor glycemic control. Although inadequate glycemic regulation is a well-established public health concern and a major contributor to diabetes-related complications, evidence on the effectiveness of intensive and supportive interventions across diverse patient subgroups is scarce. This editorial examines findings from a prospective study evaluating the influence of glycemic history on treatment outcomes in poorly controlled diabetes. The study highlights that personalized care models outperform generalized approaches by addressing the unique trajectories of glycemic deterioration. Newly diagnosed patients demonstrated the most favorable response to intervention, while those with consistently elevated glycated hemoglobin (≥ 10%) faced the greatest challenges in achieving glycemic control. These findings underscore the limitations of a one-size-fits-all strategy, reinforcing the need for patient-centered care that integrates individualized monitoring and timely intervention. Diabetes management requires prioritizing personalized treatment strategies that mitigate therapeutic inertia and ensure equitable, effective care for all patients.
Core Tip: Effective diabetes management requires personalized approaches tailored to patients’ glycemic histories. Newly diagnosed individuals show the greatest potential for achieving glycemic targets, while persistently poorly controlled patients face significant challenges. Addressing therapeutic inertia and adopting patient-centered strategies are essential to improve outcomes and bridge gaps in real-world diabetes care.
